US Patent No: 5,725,884

Number of patents in Portfolio can not be more than 2000

Pharmaceutical excipient having improved compressibility

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Importance

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Abstract

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A microcrystalline cellulose-based excipient having improved compressibility, whether utilized in direct compression, dry granulation or wet granulation formulations, is disclosed. The excipient is an agglomerate of microcrystalline cellulose particles and from about 0.1% to about 20% silicon dioxide particles, by weight of the microcrystalline cellulose, wherein the microcrystalline cellulose and silicon dioxide are in intimate association with each other. The silicon dioxide utilized in the novel excipient has a particle size from about 1 nanometer to about 100 microns. Most preferably, the silicon dioxide is a grade of colloidal silicon dioxide.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
J. RETTENMAIER & SOEHNE GMBH + CO. KGROSENBERG30

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hunter, Edward A San Diego, CA 43 518
Sherwood, Bob E Amenia, NY 43 563
Staniforth, John H Bath, GB2 12 157

Cited Art Landscape

Patent Info (Count) # Cites Year
 
FMC CORPORATION (3)
4,744,987 Coprocessed microcrystalline cellulose and calcium carbonate composition and its preparation 101 1987
5,192,569 Fat-like bulking agent for aqueous foods comprising microcrystalline cellulose and a galactomannan gum 68 1991
5,441,753 Coprocessed particulate bulking and formulating AIDS: their composition, production, and use 41 1994
 
ALZA CORPORATION (1)
4,946,685 Cellulosic dosage form 58 1988
 
BRISTOL-MYERS SQUIBB COMPANY (1)
4,664,915 Compressed and formed alkaline component suitable for use in buffered aspirin product 54 1986
 
SPB INC., 62% INTEREST (1)
4,923,981 Use of parenchymal cell cellulose to improve comestibles 44 1989
 
TCF BANK SAVINGS FSB N/K/A TCF NATIONAL BANK (1)
5,126,145 Controlled release tablet containing water soluble medicament 105 1990
 
The Procter & Gamble Company (1)
4,810,516 Reduced calorie and reduced fat chocolate confectionery compositions 64 1987

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
J. RETTENMAIER & SOEHNE GMBH + CO. KG (10)
6,395,303 Process for preparing a directly compressible solid dosage form containing microcrystalline cellulose 7 1997
5,948,438 Pharmaceutical formulations having improved disintegration and/or absorptivity 25 1997
6,103,219 Pharmaceutical excipient having improved compressibility 24 1997
6,106,865 Pharmaceutical excipient having improved compressibility 19 1998
6,217,909 Pharmaceutical excipient having improved compressibility 28 1999
6,358,533 Pharmaceutical excipient having improved compressibility 5 2001
6,866,867 Process for preparing a directly compressible solid dosage form containing microcrystalline cellulose 6 2001
6,936,277 Pharmaceutical excipient having improved compressibility 8 2002
7,179,488 Process for co-spray drying liquid herbal extracts with dry silicified MCC 2 2002
6,858,231 Pharmaceutical excipient having improved compressibility 1 2003
 
MYLAN PHARMACEUTICALS, INC. (4)
6,645,526 Storage stable thyroxine active drug formulations and methods for their production 3 2001
7,052,717 Storage stable thyroxine active drug formulations and methods for their production 1 2003
6,936,274 Storage stable thyroxine active drug formulations and methods for their production 1 2003
7,195,779 Storage stable thyroxine active drug formulations and methods for their production 1 2005
 
ACTAVIS ELIZABETH LLC (2)
6,294,198 Pharmaceutical tablet formulation containing gabapentin with improved physical and chemical characteristics and method of making the same 14 1999
6,465,012 Pharmaceutical tablet formulation containing gabapentin with improved physical and chemical characteristics and method of making the same 16 2001
 
BARR LABORATORIES, INC. (2)
7,390,503 Ondansetron orally disintegrating tablets 2 2004
7,811,604 Non-effervescent, orally disintegrating solid pharmaceutical dosage forms comprising clozapine and methods of making and using the same 0 2006
 
SCHERING CORPORATION (2)
6,335,032 Orally administrable solid dosage form 2 2000
6,337,090 Orally administrable solid ribavirin dosage forms and process for making them 3 2000
 
ALARA PHARMACEUTICAL CORPORATION (1)
6,399,101 Stable thyroid hormone preparations and method of making same 27 2000
 
Amway Corporation (1)
6,232,351 Co-processed botanical plant composition 0 1998
 
CUM PHARMA CONSULTING ANSTALT (1)
7,767,228 Pharmaceutical composition for oral application and method for preparing thereof 0 2004
 
EDWARD MENDELL & CO. (1)
6,660,303 Pharmaceutical superdisintegrant 6 2000
 
JRS Pharma LP (1)
6,753,017 Process for preparing dry extracts 3 2001
 
PROCOM ONE, INC. (1)
8,513,299 Methods of using low-dose doxepin for the improvement of sleep 0 2007
 
WATSON LABORATORIES, INC. (1)
7,838,029 Mirtazapine solid dosage forms 0 2004
 
Other [Check patent profile for assignment information] (1)
6,656,501 Oral delivery system and method for making same 7 2000