Pharmaceutical excipient having improved compressibility

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 5725884
SERIAL NO

08724613

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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A microcrystalline cellulose-based excipient having improved compressibility, whether utilized in direct compression, dry granulation or wet granulation formulations, is disclosed. The excipient is an agglomerate of microcrystalline cellulose particles and from about 0.1% to about 20% silicon dioxide particles, by weight of the microcrystalline cellulose, wherein the microcrystalline cellulose and silicon dioxide are in intimate association with each other. The silicon dioxide utilized in the novel excipient has a particle size from about 1 nanometer to about 100 microns. Most preferably, the silicon dioxide is a grade of colloidal silicon dioxide.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
J. RETTENMAIER & SOEHNE GMBH + CO. KGROSENBERG12

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hunter, Edward A Glenham, NY 32 869
Sherwood, Bob E Amenia, NY 35 936
Staniforth, John H Bath, GB2 9 283

Cited Art Landscape

Patent Info (Count) # Cites Year
 
ALZA CORPORATION (1)
* 4946685 Cellulosic dosage form 59 1988
 
SPB INC., 62% INTEREST (1)
* 4923981 Use of parenchymal cell cellulose to improve comestibles 48 1989
 
BRISTOL-MYERS SQUIBB COMPANY (1)
* 4664915 Compressed and formed alkaline component suitable for use in buffered aspirin product 62 1986
 
FMC CORPORATION (3)
* 4744987 Coprocessed microcrystalline cellulose and calcium carbonate composition and its preparation 114 1987
* 5192569 Fat-like bulking agent for aqueous foods comprising microcrystalline cellulose and a galactomannan gum 71 1991
* 5441753 Coprocessed particulate bulking and formulating AIDS: their composition, production, and use 44 1994
 
The Procter & Gamble Company (1)
* 4810516 Reduced calorie and reduced fat chocolate confectionery compositions 64 1987
 
TCF NATIONAL BANK (1)
* 5126145 Controlled release tablet containing water soluble medicament 129 1990
* Cited By Examiner

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (2)
6656501 Oral delivery system and method for making same 7 2000
* 2005/0100,600 Pharmaceutical superdisintegrant 0 2003
 
Pemix Sleep, Inc. (1)
9463181 Doxepin isomers and isomeric mixtures and methods of using the same to treat sleep disorders 0 2012
 
EDWARD MENDELL & CO. (1)
6660303 Pharmaceutical superdisintegrant 8 2000
 
ACHILLION PHARMACEUTICALS, INC. (1)
* 2011/0150,997 ELVUCITABINE PHARMACEUTICAL COMPOSITIONS 1 2007
 
ALARA PHARMACEUTICAL CORPORATION (1)
6399101 Stable thyroid hormone preparations and method of making same 45 2000
 
PENWEST PHARMACEUTICALS CO. (1)
* 2003/0099,702 Pharmaceutical excipient having improved compressibility 1 2002
 
JRS Pharma (1)
* 2010/0285,164 Orally Disintegrating Excipient 5 2009
 
PROCOM ONE, INC. (4)
8513299 Methods of using low-dose doxepin for the improvement of sleep 0 2007
* 2007/0281,990 Methods of using low-dose doxepin for the improvement of sleep 6 2007
9498462 Doxepin trans isomers and isomeric mixtures and methods of using the same to treat sleep disorders 0 2012
9486437 Methods of using low-dose doxepin for the improvement of sleep 0 2015
 
DOW GLOBAL TECHNOLOGIES LLC (1)
8992987 Polysaccharide derivatives and dosage forms 0 2012
 
SCHERING CORPORATION (2)
* 6335032 Orally administrable solid dosage form 2 2000
* 6337090 Orally administrable solid ribavirin dosage forms and process for making them 3 2000
 
JRS Pharma LP (1)
6753017 Process for preparing dry extracts 6 2001
 
The Procter & Gamble Company (1)
* 2002/0009,478 ORAL LIQUID MUCOADHESIVE COMPOSITIONS 3 1999
 
ASAHI KASEI CHEMICALS CORPORATION (2)
8951636 Composite particles which contain both cellulose and inorganic compound 1 2011
9446137 Composite particles which contain both cellulose and inorganic compound 0 2015
 
WATSON LABORATORIES, INC. (2)
7838029 Mirtazapine solid dosage forms 0 2004
* 2011/0046,115 Mirtazapine Solid Dosage Forms 0 2010
 
PERNIX SLEEP, INC. (3)
9107898 Methods of using low-dose doxepin for the improvement of sleep 0 2012
9572814 Methods of improving the pharmacokinetics of doxepin 0 2012
9532971 Low-dose doxepin formulations and methods of making and using the same 0 2013
 
MYLAN PHARMACEUTICALS, INC. (7)
6645526 Storage stable thyroxine active drug formulations and methods for their production 4 2001
7052717 Storage stable thyroxine active drug formulations and methods for their production 6 2003
6936274 Storage stable thyroxine active drug formulations and methods for their production 6 2003
* 2004/0033,259 Storage stable thyroxine active drug formulations and methods for their production 10 2003
7195779 Storage stable thyroxine active drug formulations and methods for their production 2 2005
* 2005/0232,991 Storage stable thyroxine active drug formulations and methods for their production 1 2005
* 2007/0122,476 Storage stable thyroxine active drug formulations and methods for their production 2 2007
 
Amway Corporation (1)
* 6232351 Co-processed botanical plant composition 0 1998
 
BARR LABORATORIES, INC. (2)
7390503 Ondansetron orally disintegrating tablets 6 2004
7811604 Non-effervescent, orally disintegrating solid pharmaceutical dosage forms comprising clozapine and methods of making and using the same 0 2006
 
SOMAXON PHARMACEUTICALS, INC. (4)
* 2008/0182,890 METHODS OF USING LOW-DOSE DOXEPIN FOR THE IMPROVEMENT OF SLEEP 7 2007
* 2010/0105,614 ULTRA LOW DOSE DOXEPIN AND METHODS OF USING THE SAME TO TREAT SLEEP DISORDERS 7 2007
* 2009/0074,862 LOW-DOSE DOXEPIN FORMULATIONS AND METHODS OF MAKING AND USING THE SAME 6 2008
* 2011/0166,215 METHODS OF IMPROVING THE PHARMACOKINETICS OF DOXEPIN 7 2011
 
CUM PHARMA CONSULTING ANSTALT (1)
* 7767228 Pharmaceutical composition for oral application and method for preparing thereof 0 2004
 
ACTAVIS ELIZABETH LLC (2)
6294198 Pharmaceutical tablet formulation containing gabapentin with improved physical and chemical characteristics and method of making the same 15 1999
6465012 Pharmaceutical tablet formulation containing gabapentin with improved physical and chemical characteristics and method of making the same 16 2001
 
BANK OF AMERICA, N.A. (1)
* 2003/0008,004 Pharmaceutical tablet formulation containing gabapentin with improved physical and chemical characteristics and method of making the same 0 2002
 
Udo Mattern (1)
* 2005/0186,272 Pharmaceutical composition for oral application and method for preparing thereof 3 2004
 
J. RETTENMAIER & SOEHNE GMBH + CO. KG (17)
6395303 Process for preparing a directly compressible solid dosage form containing microcrystalline cellulose 14 1997
* 5948438 Pharmaceutical formulations having improved disintegration and/or absorptivity 44 1997
* 6103219 Pharmaceutical excipient having improved compressibility 59 1997
* 6106865 Pharmaceutical excipient having improved compressibility 29 1998
6217909 Pharmaceutical excipient having improved compressibility 41 1999
6358533 Pharmaceutical excipient having improved compressibility 13 2001
* 2003/0086,982 Process for preparing dry extracts 0 2001
6866867 Process for preparing a directly compressible solid dosage form containing microcrystalline cellulose 12 2001
* 2002/0182,259 Process for preparing a directly compressible solid dosage form containing microcrystalline cellulose 0 2001
6936277 Pharmaceutical excipient having improved compressibility 17 2002
7179488 Process for co-spray drying liquid herbal extracts with dry silicified MCC 8 2002
* 2003/0206,978 Agglomerated particles including an active agent coprocessed with silicified microcrystalline cellulose 24 2002
* 2003/0203,050 Process for co-spray drying liquid herbal extracts with dry silicified MCC 1 2002
* 2003/0104,076 Process for preparing dry extracts 19 2002
6858231 Pharmaceutical excipient having improved compressibility 9 2003
* 2005/0196,439 Process for co-spray drying agents with dry silicified MCC 7 2004
* 2006/0008,522 Pharmaceutical excipient having improved compressibility 7 2005
* Cited By Examiner