Synthetic peptides for arterial imaging
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United States of America Patent
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Mar 10, 1998
Grant Date -
N/A
app pub date -
Jun 6, 1995
filing date -
May 2, 1988
priority date (Note) -
Expired
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Abstract
Vascular disease including asymptomatic atherosclerosis can be diagnosed by administering a synthetic peptide or peptide analog having an affinity for, and propensity to accumulate at, a site of vascular injury to a patient, and then detecting the location of the peptide or peptide analog within the patient's vascular system. The synthetic peptide or peptide analog may include an amino acid sequence sufficiently duplicative of the amino acid sequence of a region of either the apolipoprotein B, apolipoprotein A-I, or elastin proteins such that the peptide or peptide analog accumulates at a site of vascular injury.
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