Effervescent ranitidine formulations
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United States of America Patent
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Mar 17, 1998
Grant Date -
N/A
app pub date -
Apr 16, 1997
filing date -
Apr 16, 1997
priority date (Note) -
Expired
status (Latency Note)
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Abstract
An effervescent pharmaceutical composition for oral use in the treatment of a condition mediated through histamine H.sub.2 receptors contains a therapeutically effective amount of ranitidine or a physiologically acceptable salt thereof, about 25-70% by weight of disodium citrate, and about 20-50% by weight of sodium bicarbonate. Optionally, the effervescent composition may also Include about 0.5-25% by weight of an edible organic acid such as fumaric acid. Preferably, the effervescent composition is in the form of a tablet. Additional excipients for the effervescent composition include about 2-10% by weight of glycine, a flavoring agent, a sweetening agent, a binding agent, and/or a lubricant.
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