US Patent No: 5,728,405
Number of patents in Portfolio can not be more than 2000
Method for preventing keratocyte loss
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Mar 17, 1998
Issued date -
Jun 5, 1996
filing date -
08/658,777
serial no -
Expired
status
Importance
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Abstract
Keratocyte loss after trauma or injury to the corneal epithelium is prevented or reduced by applying to the corneal epithelium a keratocyte maintenance solution over a period of time sufficient to permit corneal wound healing. The keratocyte maintenance solution is applied to the cornea after trauma (for example, removal of the epithelium prior to surgery, such as photorefractive keratectomy). Preferably, the solution is maintained over the cornea by means of a fluid bath or by means of an absorbent material effective for controlled release of the solution to the cornea (e.g., a collagen shield substantially in the form of a conventional contact lens). A preferred keratocyte maintenance solution is a corneal storage medium.
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First Claim
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International Classification(s)
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Cited Art
| Patent Info | (Count) | # Cites | Year |
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| 5,143,731 Body cavity drug delivery with thermo-irreversible polyoxyalkylene and ionic polysaccharide gels | 51 | 1990 | |
| 5,277,911 Ablatable mask of polyoxyalkylene polymer and ionic polysaccharide gel for laser reprofiling of the cornea | 31 | 1990 | |
| 5,318,780 Medical uses of in situ formed gels | 106 | 1991 | |
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| 4,443,432 Ophthmalic irrigating solution | 37 | 1981 | |
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| 5,104,787 Method for apparatus for a defined serumfree medical solution useful for corneal preservation | 13 | 1990 | |
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| 4,837,021 Two part tissue irrigating solution | 12 | 1986 | |
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| 4,946,450 Glucan/collagen therapeutic eye shields | 37 | 1989 | |
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| 5,242,902 Defensin peptide compositions and methods for their use | 39 | 1989 | |
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| 4,695,536 Corneal storage system | 26 | 1984 | |
| 4,581,226 Method of treating sensitive animal tissue with a specially processed seawater solution | 12 | 1985 | |
| 4,886,786 Additive for irrigation solution or surgical solution | 22 | 1988 | |
| 5,380,537 Single irrigating solution used in ocular therapy for the endothelium protection and cornea preservation | 1 | 1992 | |