Isolated nucleic acid encoding receptor-like TGF-.beta.1 binding protein
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United States of America Patent
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Mar 24, 1998
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N/A
app pub date -
Dec 5, 1995
filing date -
Jun 18, 1991
priority date (Note) -
Expired
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Abstract
The invention relates to a family of substantially pure, receptor like TGF-.beta.1 binding glycoproteins. These molecules are characterized by molecular masses of 160 kd, 70-80 kd, and 30-40 kd as determined by SDS-PAGE, and the ability to bind the TGF-.beta.1 molecule. This family of molecules is useful in identifying and/or quantifying TGF-.beta.1 in a sample, as well as inhibiting its effect on cells. Also described are nucleic acid sequences which code for the protein monomer making up the molecules.
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