Tachiquinine antagonist tricyclic compounds, preparation of same and pharmaceutical compositions containing such compounds
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United States of America Patent
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Mar 24, 1998
Issued Date -
N/A
app pub date -
Oct 17, 1996
filing date -
Apr 15, 1992
priority date (Note) -
Expired
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Abstract
Tachyikinin antagonist compounds of the general formula: ##STR1## are described where: X1, X2, X3, X4, X5, and X6 are identical or different and are --NR'--CO-- or --CO--NR'--, where R' is H or C.sub.1-3 alkyl; Y is --CONR--, --NRCO--, OCO, --COO--, --CH.sub.2 --NR--, --NR--CH.sub.2 --, --SS--, --CH.sub.2 --CH.sub.2 --, cis or trans --CH.dbd.CH-- where R is H or C.sub.1-3 alkyl; R1, R2, R3, and R4 are each a hydrophobic group; n and m are identical or different and are each a whole number from 1 to 4. The preparation and pharmaceutical compositions of the compounds are also disclosed.
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