C.sup.ac -methylphosphonamidites and methods for preparing methylphosphonates
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United States of America Patent
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Mar 24, 1998
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N/A
app pub date -
Oct 18, 1995
filing date -
Oct 18, 1995
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Abstract
A compound of general formula ##STR1## wherein R is methyl R' is selected from the group consisting of trityl and pixyl, and R' is H or OMe. These compounds may advantageously be employed in the synthesis of oligonucleotides by conventional methods, such as automated solid phase synthesis. Use of ethylene diamine in the cleavage and deprotection procedure substantially eliminates the formation of undesirable side products.
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