Process for fixation of calcification-resistant biological tissue
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United States of America Patent
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Mar 31, 1998
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N/A
app pub date -
Sep 24, 1996
filing date -
Feb 17, 1994
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Abstract
A process is provided for non-glutaraldehyde fixation of an organ or prosthesis to be implanted in a mammal. The process produces stable fixation of the tissue by forming amide linkages within and between the molecules of the tissue and employs a coupling agent, such as EDC, in combination with a coupling enhancer, such as Sulfo-NHS; diamine and/or dicarboxyl cross-linking agents are optionally included. In addition to fixing the tissue, the process prevents or retards calcification and results in a nontoxic product that does not cause inflammation.
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