Ligand precursors for incorporation into peptides
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United States of America Patent
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Mar 31, 1998
Grant Date -
N/A
app pub date -
Jun 6, 1995
filing date -
May 14, 1993
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
Compositions and methods of incorporating ligand precursors and ligands at any location within a peptide during peptide synthesis are disclosed. Derivatives of 2,4,5-triaminopentanoic acid and .gamma.-aminoglutamic acid are selectively incorporated into the peptide during solid phase or liquid phase synthesis, depending upon the choice of protecting groups. Ligand synthesis may then be completed at a later time to produce N.sub.3 S, N.sub.2 S.sub.2, and EDTA type chelating agents.
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