Benzoxazines for enhancing synaptic response
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United States of America Patent
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Apr 7, 1998
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N/A
app pub date -
Apr 3, 1996
filing date -
Apr 3, 1996
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Abstract
Compounds based on the benzoxazine ring system ##STR1## are disclosed for use in enhancing synaptic responses mediated by AMPA receptors. The compounds are effective in the treatment of subjects suffering from impaired nervous or intellectual functioning due to deficiencies in the number or strength of excitatory synapses or in the number of AMPA receptors. The compounds can also be used for the treatment of non-impaired subjects for enhancing performance in sensory-motor and cognitive tasks which depend on brain networks utilizing AMPA receptors, for improving the performance of subjects with memory deficiencies, for treating schizophrenia, and for improving memory encoding.
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