Materials and their use in the preparation of biocompatible surfaces
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United States of America Patent
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Apr 14, 1998
Grant Date -
N/A
app pub date -
Jul 29, 1996
filing date -
Jan 28, 1994
priority date (Note) -
Expired
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Abstract
New materials having improved biocompatibility have novel zwitterionic groups at the surface. The zwitterion is characterized by having at least one monovalent substituent at the atom carrying the cationic charge which is an aryl group. Preferably the atom carries at least two, and preferably three such aryl, usually phenyl, groups. The cationic group is preferably a triphenylphosphonium. Treatment of surfaces to provide pendant zwitterionic groups of the specified type have reduced platelet activation, whilst they do not appear to reduce platelet adhesion. The invention has utility in the field of blood contacting device, especially devices for implantation, such as vascular grafts.
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