Safe vectors for gene therapy
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United States of America Patent
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Apr 21, 1998
Issued Date -
N/A
app pub date -
Jun 6, 1995
filing date -
May 24, 1994
priority date (Note) -
Expired
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Abstract
The present invention provides retroviral vectors comprising direct repeats flanking a sequence that is desired to be deleted upon reverse transcription in a host cell. In a preferred embodiment the sequence that is desired to be deleted is the retroviral cis-acting encapsidation sequence (E) essential for virus production in helper cells. In gene therapy embodiments, the E sequence is deleted upon reverse transcription in target cells, thus preventing spread of retroviral vectors to non-target cells in the event of infection with replication competent viruses. The retroviral vectors of the present invention thus provide safe vectors for gene therapy.
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