Useful mutations of bacterial alkaline protease

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United States of America Patent

PATENT NO 5741694
SERIAL NO

08486415

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Abstract

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The present invention relates to mutations of the subtilisin gene, some of which result in changes in the chemical characteristics of subtilisin enzyme. Mutations are created at specific nucleic acids of the subtilisin gene and, in various specific embodiments, the mutant enzymes possess altered chemical properties including, but not limited to, increased stability to oxidation, augmented proteolytic activity, and improved washability. The present invention also relates, but is not limited to, the amino acid and DNA sequences for two proteases derived from Bacillus lentus variants, subtilisin 147 and subtilisin 309, as well as mutations of these genes and the corresponding mutant enzymes.

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Patent Owner(s)

Patent OwnerAddress
NOVOZYMES A/SDENMARK BAGSVAERD BAGSVAERD REGION HOVEDSTADEN

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Aaslyng, Dorrit Roskilde, DK 16 379
Branner, Sven Lyngby, DK 24 590
Hastrup, Sven K.o slashed.benhavn NV, DK 27 591
Jensen, Villy Johannes Bagsvaerd, DK 6 125
No, slashedrskov-Lauridsen Leif K.o slashed.ge, DK 4 93
Norris, Fanny Hellerup, DK 22 311
Petersen, Steffen Bjo slashedrn Ballerup, DK 3 84

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