Process for preparing covalently bound-heparin containing polyurethane-peo-heparin coating compositions
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United States of America Patent
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Apr 21, 1998
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N/A
app pub date -
Nov 25, 1996
filing date -
Nov 25, 1996
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Abstract
A bio-active coating composition is described which is the reaction product of two different reactions. The first reaction includes reacting a bio-compatible polymer backbone having .alpha.,.beta.-unsaturated carbonyl functionality with a hydrophilic spacer having at least one reactive functional group at its first and second ends. In this reaction, one of the reactive functional groups of the spacer reacts with a .beta.-carbon of the carbonyl functionality to bond the spacer to the polymer backbone. The second reaction includes reacting a bio-active agent with a remaining unreacted reactive functional group of the spacer in the presence of an optional catalyst to covalently bind the bio-active agent to the spacer.
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