Methods for the detection of soluble amyloid .beta.-protein (.beta.AP) or soluble transthyretin (TTR)
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United States of America Patent
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Apr 28, 1998
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N/A
app pub date -
Nov 4, 1993
filing date -
Nov 4, 1993
priority date (Note) -
Expired
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Abstract
This invention is directed to methods and compositions for preventing aggregation of amyloid .beta.-protein (.beta.AP) aggregation. Aggregation of amyloid .beta.-protein is associated with the deposition of amyloid in the brain. Amyloid .beta.-protein-binding compounds such as transthyretin are described which form complexes with .beta.AP and prevent formation of amyloid. This invention also identifies the serine 6 mutation in the TTR gene as predictive of person at risk for developing .beta.AP associated amyloidosis.
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