Method for increasing the electrotransport flux of polypeptides
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United States of America Patent
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May 5, 1998
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app pub date -
Jun 6, 1995
filing date -
Jun 6, 1995
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Abstract
Methods for modifying polypeptide agents to enhance their transdermal electrotransport flux are provided. The polypeptide is modified by reducing the potential of the polypeptide for forming .alpha.-helical or .beta.-sheet segments. In particular, amino acid residues known to stabilize .alpha.-helical and .beta.-sheet segments can be replaced with destabilizing residues and known helix breakers. Modified molecules and compositions including the molecules are also provided.
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