Erythromycins

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United States of America Patent

PATENT NO 5747467
SERIAL NO

08767954

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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A compound selected from the group consisting of a compound of the formula ##STR1## wherein X is selected from the group consisting of --(NH).sub.a --, --CH.sub.2 --, --SO.sub.2 -- and --O--, a is 0 or 1, Y is --(CH.sub.2).sub.m - (CH.dbd.CH).sub.n --(CH.sub.2).sub.o -, m+n+o.ltoreq.8, n=o or 1, Ar is aryl optionally substituted with at least one member of the group consisting of --OH, halogen, --NO.sub.2, --CN, ##STR2## and alkyl, alkenyl, alkynyl, alkoxy, alkenyloxy, alkynyloxy, alkylthio, alkenylthio, alkynylthio, -N-alkyl, -N-alkenyl and N-alkynyl of up to 12 carbon atoms, R.sub.a and R.sub.b individually are hydrogen or alkyl of up to 12 carbon atoms, R.sub.3 is selected from the group consisting of alkyl of 1 to 12 carbon atoms, aryl, heteroaryl, carbocyclic aryl, aryloxy, arylthio and heterocyclic aryl, heterocyclic aryloxy and heterocyclic arylthio of 5 to 6 ring members containing at least one heteroatom, Hal is halogen, Z is hydrogen or acyl of an organic carboxylic acid and their non-toxic, pharmaceutically acceptable addition salts having antibacterial properties.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
AVENTIS PHARMA S.A.ANTONY416

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Agouridas, Constantin Nogent sur Marne, FR 30 487
Bretin, Francedillaois Ozoir la Ferriere, FR 1 47
Chantot, Jean-Francedillaois Nogent sur Marne, FR 5 125

Cited Art Landscape

Patent Info (Count) # Cites Year
 
AVENTIS PHARMA S.A. (2)
* 5444051 Erythromycin compounds 76 1993
* 5527780 Erythromycin derivatives 67 1993
* Cited By Examiner

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (2)
* 2005/0215,495 Macrolide antibiotics 1 2005
9815863 Hydrogen bond forming fluoro ketolides for treating diseases 0 2011
 
MERCK SHARP & DOHME CORP. (5)
7601695 Antibacterial agents 13 2004
* 2006/0100,164 Novel antibacterial agents 15 2004
8012943 Antibacterial agents 2 2009
8343936 Antibacterial agents 0 2011
9200026 Antibacterial agents 2 2012
 
ABBOTT LABORATORIES (1)
* 6124269 2-Halo-6-O-substituted ketolide derivatives 52 1998
 
HOECHST MARION ROUSSEL (1)
* 6455505 Derivatives . . . use as medicaments 17 1999
 
Ortho-McNeil Pharmaceutical, Inc. (3)
6458771 Ketolide antibacterials 6 2000
6399582 Ketolide antibacterials 32 2000
6590083 Ketolide antibacterials 7 2000
 
GlaxoSmithKline Istrazivacki Centar Zagreb (1)
7157433 Compounds, compositions as carriers for steroid/nonsteroid anti-inflammatory; antienoplastic and antiviral active molecules 1 2003
 
ABBVIE INC. (1)
6355620 C-2 modified erythromycin derivatives 16 1999
 
PLIVA D.D. (1)
* 2004/0077,557 Macrolide antibiotics 7 2003
 
MELINTA THERAPEUTICS, INC. (7)
7091196 Bifunctional heterocyclic compounds and methods of making and using same 7 2003
* 2005/0197,334 Bifunctional heterocyclic compounds and methods of making and using same 1 2003
8202843 Macrocyclic compounds and methods of making and using the same 1 2005
* 2008/0045,585 Macrocyclic Compounds And Methods Of Making And Using The Same 6 2005
7335753 Bifunctional heterocyclic compounds and methods of making and using same 12 2006
* 2006/0264,385 Bifunctional heterocyclic compounds and methods of making and using same 11 2006
8841263 Macrocyclic compounds and methods of making and using the same 0 2012
 
PFIZER INC. (5)
* 6555524 Ketolide antibiotics 15 2001
* 6833444 Ketolide antibiotics 2 2002
6777543 13-methyl erythromycin derivatives 4 2003
* 2003/0229,031 13-Methyl erythromycin derivatives 0 2003
7462600 Macrolides 0 2005
 
Pliva dd (1)
* 2004/0077,612 Novel compounds, compositions as carriers for steroid/nonsteroid anti-inflammatory; antienoplastic and antiviral active molecules 3 2003
 
GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (2)
7091187 Compounds, compositions and methods for treatment of inflammatory diseases and conditions 4 2003
* 2004/0014,685 Compounds, compositions and methods for treatment of inflammatory diseases and conditions 7 2003
 
KOSAN BIOSCIENCES, INC. (9)
6451768 Macrolide antiinfective agents 5 2000
6395710 Macrolide antiinfective agents 23 2000
6514944 Macrolide antiinfective agents 6 2000
6593302 Macrolide antiinfective agents 5 2002
6794366 Macrolide antiinfective agents 2 2002
6939861 Amido macrolides 1 2003
* 2003/0199,458 Amido macrolides 0 2003
6762168 Macrolide antiinfective agents 4 2003
RE39836 Macrolide antinfective agents 1 2005
 
PFIZER PRODUCTS INC. (2)
6664238 Carbamate and carbazate ketolide antibiotics 19 1999
6809080 Macrolide antibiotics 0 2001
 
AVENTIS PHARMA S.A. (5)
* 6162793 Erythromycin derivatives, method for preparing same and use thereof as drugs 4 1999
* 6121432 Erythromycins 29 1999
* 6440941 Derivatives of erythromycin, their preparation process and their use as medicaments 21 1999
* 6313101 Derivatives of erythromycin, their preparation process and their use as medicaments 9 2000
* 6706692 6-deoxy erythromycin derivatives, method for preparing same and use as medicines 0 2001
 
RANBAXY LABORATORIES LIMITED (2)
* 2008/0287,376 Ketolide Derivatives as Antibacterial Agents 14 2005
* 2009/0130,225 MACROLIDES DERIVATIVES AS ANTIBACTERIAL AGENTS 1 2006
 
RIB-X PHARMACEUTICALS, INC. (2)
* 2007/0072,811 Bifunctional heterocyclic compounds and methods of making and using the same 2 2004
* 2007/0149,463 Bifunctional macrolide heterocyclic compounds and methods of making and using the same 5 2004
 
CEMPRA PHARMACEUTICALS, INC. (13)
9453042 Process for the preparation of macrolide antibacterial agents 0 2008
9072759 Biodefenses using triazole-containing macrolides 0 2009
8796232 Methods for treating resistant diseases using triazole containing macrolides 9 2009
8791080 Methods for treating gastrointestinal diseases 10 2009
* 2011/0237,534 METHODS FOR TREATING GASTROINTESTINAL DISEASES 0 2009
* 2011/0195,920 BIODEFENSES USING TRIAZOLE-CONTAINING MACROLIDES 9 2009
9480679 Methods for treating malaria, tuberculosis and MAC diseases 0 2010
8975386 Crystalline forms of a macrolide, and uses therefor 0 2011
9051346 Process for preparing triazole-containing ketolide antibiotics 4 2011
8759500 Crystalline forms of a macrolide, and uses therefor 0 2013
9751908 Convergent processes for preparing macrolide antibacterial agents 0 2014
9439918 Methods for treating gastrointestinal diseases 0 2014
9669046 Biodefenses using triazole-containing macrolides 0 2015
* Cited By Examiner