US Patent No: 5,747,467

Number of patents in Portfolio can not be more than 2000

Erythromycins

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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A compound selected from the group consisting of a compound of the formula ##STR1## wherein X is selected from the group consisting of --(NH).sub.a --, --CH.sub.2 --, --SO.sub.2 -- and --O--, a is 0 or 1, Y is --(CH.sub.2).sub.m - (CH.dbd.CH).sub.n --(CH.sub.2).sub.o -, m+n+o.ltoreq.8, n=o or 1, Ar is aryl optionally substituted with at least one member of the group consisting of --OH, halogen, --NO.sub.2, --CN, ##STR2## and alkyl, alkenyl, alkynyl, alkoxy, alkenyloxy, alkynyloxy, alkylthio, alkenylthio, alkynylthio, -N-alkyl, -N-alkenyl and N-alkynyl of up to 12 carbon atoms, R.sub.a and R.sub.b individually are hydrogen or alkyl of up to 12 carbon atoms, R.sub.3 is selected from the group consisting of alkyl of 1 to 12 carbon atoms, aryl, heteroaryl, carbocyclic aryl, aryloxy, arylthio and heterocyclic aryl, heterocyclic aryloxy and heterocyclic arylthio of 5 to 6 ring members containing at least one heteroatom, Hal is halogen, Z is hydrogen or acyl of an organic carboxylic acid and their non-toxic, pharmaceutically acceptable addition salts having antibacterial properties.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
AVENTIS PHARMA S.A.ANTONY448

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Agouridas, Constantin Nogent sur Marne, FR 33 369
Bretin, Francedillaois Ozoir la Ferriere, FR 1 38
Chantot, Jean-Francedillaois Gressy en France, FR 5 97

Cited Art Landscape

Patent Info (Count) # Cites Year
 
AVENTIS PHARMA S.A. (2)
* 5,444,051 Erythromycin compounds 67 1993
* 5,527,780 Erythromycin derivatives 58 1993
* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
HOECHST MARION ROUSSEL (1)
* 6,455,505 Derivatives . . . use as medicaments 8 1999
 
ORTHO-MCNEIL PHARMACEUTICAL, INC. (3)
6,458,771 Ketolide antibacterials 6 2000
6,399,582 Ketolide antibacterials 32 2000
6,590,083 Ketolide antibacterials 7 2000
 
GlaxoSmithKline istrazivacki centar Zagreb (1)
7,157,433 Compounds, compositions as carriers for steroid/nonsteroid anti-inflammatory; antienoplastic and antiviral active molecules 1 2003
 
OPTIMER PHARMACEUTICALS, INC. (3)
7,601,695 Antibacterial agents 4 2004
8,012,943 Antibacterial agents 0 2009
8,343,936 Antibacterial agents 0 2011
 
MELINTA THERAPEUTICS, INC. (4)
7,091,196 Bifunctional heterocyclic compounds and methods of making and using same 6 2003
8,202,843 Macrocyclic compounds and methods of making and using the same 1 2005
7,335,753 Bifunctional heterocyclic compounds and methods of making and using same 9 2006
8,841,263 Macrocyclic compounds and methods of making and using the same 0 2012
 
ABBVIE INC. (1)
6,355,620 C-2 modified erythromycin derivatives 16 1999
 
PFIZER INC. (4)
* 6,555,524 Ketolide antibiotics 6 2001
* 6,833,444 Ketolide antibiotics 2 2002
6,777,543 13-methyl erythromycin derivatives 2 2003
7,462,600 Macrolides 0 2005
 
GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (1)
7,091,187 Compounds, compositions and methods for treatment of inflammatory diseases and conditions 4 2003
 
KOSAN BIOSCIENCES, INC. (8)
6,451,768 Macrolide antiinfective agents 5 2000
6,395,710 Macrolide antiinfective agents 14 2000
6,514,944 Macrolide antiinfective agents 6 2000
6,593,302 Macrolide antiinfective agents 5 2002
6,794,366 Macrolide antiinfective agents 2 2002
6,939,861 Amido macrolides 1 2003
6,762,168 Macrolide antiinfective agents 4 2003
RE39836 Macrolide antinfective agents 1 2005
 
PFIZER PRODUCTS INC. (2)
6,664,238 Carbamate and carbazate ketolide antibiotics 10 1999
6,809,080 Macrolide antibiotics 0 2001
 
AVENTIS PHARMA S.A. (5)
* 6,162,793 Erythromycin derivatives, method for preparing same and use thereof as drugs 4 1999
* 6,121,432 Erythromycins 20 1999
* 6,440,941 Derivatives of erythromycin, their preparation process and their use as medicaments 11 1999
* 6,313,101 Derivatives of erythromycin, their preparation process and their use as medicaments 4 2000
* 6,706,692 6-deoxy erythromycin derivatives, method for preparing same and use as medicines 0 2001
 
ABBOTT LABORATORIES (1)
* 6,124,269 2-Halo-6-O-substituted ketolide derivatives 51 1998
 
CEMPRA PHARMACEUTICALS, INC. (4)
8,796,232 Methods for treating resistant diseases using triazole containing macrolides 0 2009
8,791,080 Methods for treating gastrointestinal diseases 1 2009
8,975,386 Crystalline forms of a macrolide, and uses therefor 0 2011
8,759,500 Crystalline forms of a macrolide, and uses therefor 0 2013
* Cited By Examiner