Method of preventing NMDA receptor complex-mediated Neuronal damage
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United States of America Patent
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May 5, 1998
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app pub date -
Mar 22, 1995
filing date -
Apr 4, 1991
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Abstract
Disclosed is a method for decreasing NMDA receptor-mediated neuronal damage in a mammal by administering to the mammal a nitroso-compound that generates nitric-oxide or related redox species, in a concentration effective to effect neuroprotection. Also disclosed is a method for decreasing NMDA receptor-mediated neuronal damage in a mammal by administering to the mammal a nitroso-compound that generates nitric oxide (or a related redox species such as NO.sup.- or NO.sup.+ equivalent), or a physiologically concentration effective to cause such neuroprotection.
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