Formation and use of prion protein (PRP) complexes
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United States of America Patent
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May 12, 1998
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N/A
app pub date -
Nov 2, 1995
filing date -
Nov 2, 1995
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Expired
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Abstract
Prion protein (PrP) peptides having at least one .alpha.-helical domain and forming a random coil conformation in aqueous solutions bind cellular PrP (PrP.sup.C) to form a complex having characteristics of the scrapie isoform (PrP.sup.Sc). Methods for screening compounds able to inhibit or decrease the binding of PrP peptides to PrP.sup.C are disclosed, as well as methods for assaying PrP.sup.Sc.
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