Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents

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United States of America Patent

PATENT NO 5750688
SERIAL NO

08629862

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Abstract

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Novel processes are provided for producing compounds of formula II ##STR1## wherein R.sup.1 and R.sup.2 each are independently C.sub.1 -C.sub.4 alkyl, or combine to form piperidinyl, pyrrolidinyl, methylpyrrolidinyl, dimethylpyrrolidinyl, morpholino, dimethylamino, diethylamino, or 1-hexamethyleneimino; R.sup.3 and R.sup.4 each are H or a hydroxy protecting group; and n is 2 or 3; or a pharmaceutically acceptable salt thereof by reacting a haloalkylamine with a phenolic ester in the presence of an alkylacetate solvent and a base.

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Patent Owner(s)

  • ELI LILLY AND COMPANY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kjell, Douglas P West Lafayette, IN 9 182
Perry, Fred M West Lafayette, IN 2 3

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