Separation of the enantiomers of amlodipine via their diastereomeric tartrates
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United States of America Patent
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May 12, 1998
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N/A
app pub date -
Sep 18, 1996
filing date -
Mar 24, 1994
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Abstract
A method for the separation of R-(+)- and S-(-)-isomers of amlodipine (I) from mixtures thereof, which comprises the reaction of the mixture of isomers with either L- or D-tartaric acid in an organic solvent containing sufficient dimethyl sulphoxide (DMSO) for the precipitation of, respectively, a DMSO solvate of an L-tartrate salt of R-(+)-amlodipine, or a DMSO solvate of a D-tartrate salt of S-(-)-amlodipine. ##STR1##
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