Lipid-coated condensed-phase microparticle composition
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United States of America Patent
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May 19, 1998
Issued Date -
N/A
app pub date -
May 17, 1995
filing date -
Feb 12, 1993
priority date (Note) -
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Abstract
A microparticle composition for use in compound delivery, when the composition is exposed to a selected target stimulus related to pH, temperature, radiation, or the presence of a selected ligand or ion-channel activator, is disclosed. The composition includes a condensed-phase particle matrix containing the compound to be delivered in entrapped form, and a stimulus-responsive lipid bilayer membrane formed around the matrix. Localized perturbation of the lipid membrane, and influx of monovalent counterions into the polymer matrix, in response to the selected target stimulus, causes matrix swelling and compound release from the particles.
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