Heterodimeric receptor libraries using phagemids

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United States of America Patent

PATENT NO 5759817
SERIAL NO

08322730

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Filamentous phage comprising a matrix of cpVIII proteins encapsulating a genome encoding first and second polypeptides of an antogenously assembling receptor, such as an antibody, and a receptor comprised of the first and second polypeptides surface-integrated into the matrix via a cpVIII membrane anchor domain fused to at least one of the polypeptides with a mutagenized CDR3 region.

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Patent Owner(s)

  • THE SCRIPPS RESEARCH INSTITUTE

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Barbas, Carlos San Diego, CA 5 689

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