Cytokine restraining agents and methods of use in pathologies and conditions associated with altered cytokine levels
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United States of America Patent
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Jun 2, 1998
Issued Date -
N/A
app pub date -
May 22, 1995
filing date -
Mar 6, 1995
priority date (Note) -
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Abstract
The present invention relates to novel peptides that are potent cytokine restraining agents. In addition, the present invention relates to pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a cytokine restraining agent. Administration of such a cytokine restraining agent to a subject restrains, but does not necessarily suppress, cytokine activity completely. Thus, the present invention provides a method of restraining pathologically elevated cytokine activity in a subject. The invention also provides methods of treating disuse deconditioning and diseases mediated by nitric oxide and cytokines, such as diabetes and glomerulonephritis, a method of organ protection, a method of organ protection, and a method of reducing the negative side effects of cancer chemotherapy, such as nephrotoxicity.
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