Potent penetration enhancers
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United States of America Patent
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Jun 2, 1998
Grant Date -
N/A
app pub date -
Oct 18, 1996
filing date -
Oct 18, 1996
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The epidermal permeability barrier to systemically and/or topically active agents or compositions designed for topical administration is enhanced to an unexpected degree by certain combinations of known penetration enhancing excipients. One group of combinations comprise a glycol and an alcohol at a weight ratio within the range of 1:0.1 to 1:10 with one or more further additives, selected from the excipient groups of branched-chain esters of fatty acids, surfactants, and membrane fluidizers. Another group of combinations comprise an alcohol of four or more carbon atoms and one or more further additives selected from the excipient groups of glycols and surfactants.
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