Blood contact surfaces employing natural subendothelial matrix and methods for making and using the same
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United States of America Patent
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Jun 9, 1998
Issued Date -
N/A
app pub date -
Jun 18, 1996
filing date -
Apr 29, 1994
priority date (Note) -
Expired
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Abstract
This invention relates to improved vascular prostheses derived from mammalian blood vessels. The prostheses are fabricated from arterial segments from which the donor endothelium has been removed. A key aspect of this invention is the preservation of the subendothelial extracellular matrix that will serve as the blood interface of the vascular prostheses. The vessel segments are treated to reduce the likelihood of calcification and fixed with a tissue preservative. This invention results in vascular prostheses that are particularly useful for small diameter applications, such as arterial replacement requiring a diameter of 6 mm or less.
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