Transdermal propentofylline compositions for the treatment of Alzheimers disease
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United States of America Patent
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Jun 9, 1998
Grant Date -
N/A
app pub date -
Aug 22, 1996
filing date -
Aug 22, 1996
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
Patients suffering from Alzheimer's disease are treated by transdermally administering an effective amount of propentofylline in the form of an occulsive device containing a delivery composition comprising a carrier vehicle having uniformly distributed therein effective amounts of propentofylline and, optionally, a penetration enhancer. The occulsive device may be a matrix type patch in which the carrier vehicle is a pressure sensitive adhesive or a reservoir type patch in which the carrier vehicle is a liquid of controlled viscosity, i.e. a gel, wherein the reservoir system contains means for maintaining it in a propentofylline transferring relationship with the derma when applied. Daily dosages of between about 5 and 49 mg/day are sufficient to maintain adequate plasma propentofylline levels.
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