Gene transfer into bone cells and tissues
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United States of America Patent
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Jun 9, 1998
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N/A
app pub date -
Feb 18, 1994
filing date -
Feb 18, 1994
priority date (Note) -
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Abstract
Disclosed are methods, compositions and devices for use in transferring nucleic acids into bone cells in situ. The transfer of an osteotropic gene into bone progenitor cells is described, which event is shown to stimulate the progenitor cells and to promote bone growth, repair and regeneration in vivo. These gene transfer protocols are suitable for use in transferring various nucleic acid materials into bone, and have many uses, for example, in treating various bone-related diseases and defects, such as, in promoting fracture repair, use in connection with implants, and in treating osteoporosis and osteogenesis imperfecta.
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