Composition and method for storing nucleotide analogs
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United States of America Patent
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Jun 9, 1998
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N/A
app pub date -
Mar 26, 1996
filing date -
Mar 26, 1996
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Abstract
The invention provides compositions and methods to prevent the appearance of visually detectable precipitate in the composition upon storage of an aqueous solution of the composition containing 5-250 mg/mL of the phosphonate nucleotide analog for at least 6 months at 22.degree. where the composition comprises a phosphonate nucleotide analog and a sufficient amount of a divalent or trivalent metal cation sequestering agent such as about 0.1% w/v EDTA, and/or a sufficiently low concentration of a divalent or trivalent metal cation, e.g., about 3-10 ppm, and/or a sufficient pH in water, e.g., a pH of about 7.0-7.5.
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