US Patent No: 5,770,212
Number of patents in Portfolio can not be more than 2000
Recombinant poxviruses with foreign DNA in essential regions
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Jun 23, 1998
Issued date -
Feb 21, 1997
filing date -
08/802,985
serial no -
Expired
status
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Abstract
Defective poxviruses that lack a function imparted by an essential region of its parental poxvirus are provided for protein production and vaccination. A DNA polynucleotide encoding a protein is inserted into the defective poxvirus and placed under transcriptional control of a promoter. The defective poxvirus is viable when the lost function of the essential region is complemented by a host cell, transgenic animal or helper virus.
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First Claim
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International Classification(s)
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Cited Art
| Patent Info | (Count) | # Cites | Year |
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| 4,722,848 Method for immunizing animals with synthetically modified vaccinia virus | 103 | 1984 | |
| 5,204,243 Recombinant poxvirus internal cores | 27 | 1990 | |
| 5,338,683 Vaccinia virus containing DNA sequences encoding herpesvirus glycoproteins | 53 | 1990 | |
| 5,174,993 Recombinant avipox virus and immunological use thereof | 80 | 1990 | |
| 5,225,336 Recombinant poxvirus host range selection system | 58 | 1992 | |
| 5,505,941 Recombinant avipox virus and method to induce an immune response | 44 | 1992 | |
| 5,453,364 Recombinant poxvirus host range selection system | 31 | 1993 | |
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| 5,494,807 NYVAC vaccinia virus recombinants comprising heterologous inserts | 89 | 1993 | |
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| 5,364,773 Genetically engineered vaccine strain | 56 | 1993 | |