Method and aparatus for determining an analyte in a biological sample

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 5770454
SERIAL NO

08737135

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Abstract

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A method and apparatus for analytical determination of a concentration of an analyte in a biological sample include a series of hardware elements and method steps which perform at least two detection measurements, with each detection measurement including the step of irradiating light at an irradiation site as primary light into the biological sample through a boundary surface. The light is propagated along a light path, and light is detected as it emerges from the biological sample as secondary light through a detection site. The irradiation site and detection site are separated by a measuring distance. At least two detection measurements are performed with at least two different measurement light paths between the irradiation site and the detection site. Each of the detection measurements is a frequency-domain spectroscopic measurement which is performed at at least two different wavelengths of light, and includes a comparison of a phase shift of the secondary light with the primary light as a first measurement variable, and an intensity of the secondary light as a second measurement variable. The method also includes the steps of determining the analyte concentration based upon the first and second measurement variables.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
BOEHRINGER MANNHEIM GMBHMANNHEIM171

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Boecker, Dirk Heidelberg, DE 138 18027
Essenpreis, Matthias Gauting, DE 27 2660
Haar, Hans-Peter Wiesloch, DE 88 4630
Hein, Heinz-Michael Seeheim-Jugenheim, DE 18 612

Cited Art Landscape

Patent Info (Count) # Cites Year
 
I.S.S. (USA), INC. (1)
* 5497769 Photosensor with multiple light sources 73 1993
 
HAMAMATSU PHOTONICS K.K. (4)
* 5441054 Apparatus for measuring absorption information in scattering medium and method therefor 55 1993
* 5477051 Apparatus for measuring optical information in scattering medium and method therefor 42 1993
* 5517987 Method for measuring internal information in scattering medium and apparatus for the same 60 1994
* 5529065 Method for measuring scattering medium and apparatus for the same 38 1994
 
WELLS, STEPHEN (1)
* 5277181 Noninvasive measurement of hematocrit and hemoglobin content by differential optical analysis 259 1991
 
BOEHRINGER MANNHEIM GMBH (2)
* 5551422 Method and apparatus for analytical determination of glucose in a biological matrix 135 1994
* 5507288 Analytical system for monitoring a substance to be analyzed in patient-blood 1013 1995
 
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (1)
* 5137355 Method of imaging a random medium 76 1989
 
NON-INVASIVE TECHNOLOGY, INC. (1)
* 4972331 Phase modulated spectrophotometry 228 1989
* Cited By Examiner

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Patent Info (Count) # Cites Year
 
MINOLTA CO., LTD. (1)
* 6847835 Transcutaneous bilirubin concentration measuring apparatus and a measurement data checking plate for use with the same 32 2000
 
GLENN PATENT GROUP (4)
* 2005/0054,908 Photostimulation method and apparatus in combination with glucose determination 150 2004
* 2006/0211,927 Compact apparatus for noninvasive measurement of glucose through near-infrared spectroscopy 125 2006
* 2006/0173,255 Compact apparatus for noninvasive measurement of glucose through near-infrared spectroscopy 122 2006
* 2006/0116,562 Compact apparatus for noninvasive measurement of glucose through near-infrared spectroscopy 125 2006
 
ABBOTT DIABETES CARE INC. (1)
7043287 Method for modulating light penetration depth in tissue and diagnostic applications using same 202 1999
 
TYCO HEALTHCARE GROUP LP (1)
* 6343223 Oximeter sensor with offset emitters and detector and heating device 125 2000
 
CAS MEDICAL SYSTEMS, INC. (14)
6456862 Method for non-invasive spectrophotometric blood oxygenation monitoring 134 2001
7047054 Laser diode optical transducer assembly for non-invasive spectrophotometric blood oxygenation monitoring 69 2001
* 2002/0016,536 Laser diode optical transducer assembly for non-invasive spectrophotometric blood oxygenation monitoring 19 2001
7072701 Method for spectrophotometric blood oxygenation monitoring 129 2003
* 2004/0024,297 Method for spectrophotometric blood oxygenation monitoring 41 2003
8078250 Method for spectrophotometric blood oxygenation monitoring 2 2006
7313427 Laser diode optical transducer assembly for non-invasive spectrophotometric blood oxygenation 66 2006
* 2006/0195,024 Laser diode optical transducer assembly for non-invasive spectrophotometric blood oxygenation 3 2006
8396526 Method for spectrophotometric blood oxygenation monitoring 4 2006
8391942 Method and apparatus for determining cerebral desaturation in patients undergoing deep hypothermic circulatory arrest 0 2009
* 2010/0087,719 METHOD AND APPARATUS FOR DETERMINING CEREBRAL DESATURATION IN PATIENTS UNDERGOING DEEP HYPOTHERMIC CIRCULATORY ARREST 3 2009
* 2010/0105,998 METHOD AND APPARATUS FOR SPECTROPHOTOMETRIC BASED OXIMETRY OF SPINAL TISSUE 1 2009
8788004 Method for spectrophotometric blood oxygenation monitoring 0 2011
8923943 Method for spectrophotometric blood oxygenation monitoring 0 2013
 
BIOMERIEUX, INC. (4)
8512975 Method for detection and characterization of a microorganism in a sample using time dependent spectroscopic measurements 1 2009
* 2010/0068,755 Method and system for detection and/or characterization of a biological particle in a sample 12 2009
* 2010/0124,763 Method for detection, characterization and/or identification of microorganisms in a sealed container 1 2009
8709748 Method for detection and characterization of a microorganism in a sample using time-dependent intrinsic fluorescence measurements 0 2013
 
HAMAMATSU PHOTONICS K.K. (4)
* 5983121 Absorption information measuring method and apparatus of scattering medium 17 1997
6240305 Method and apparatus for measuring absorption information of a scattering medium 111 1999
6236871 Absorption information measuring method and apparatus of scattering medium 99 1999
6233470 Absorption information measuring method and apparatus of scattering medium 99 1999
 
FACET TECHNOLOGIES, LLC (10)
7377904 Cap displacement mechanism for lancing device and multi-lancet cartridge 20 2005
7837633 Lancing device and multi-lancet cartridge 5 2005
8870903 Blood sampling device 2 2006
* 2008/0082,117 LANCING DEVICE 115 2007
* 2008/0039,887 LANCING DEVICE AND MULTI-LANCET CARTRIDGE 101 2007
8298255 Cap displacement mechanism for lancing device and multi-lancet cartridge 1 2007
8221332 Multi-lancet cartridge and lancing device 4 2008
* 2010/0057,119 MULTI-LANCET CARTRIDGE AND LANCING DEVICE 3 2008
* 2010/0094,326 MULTI-LANCET CARTRIDGE AND LANCING DEVICE 1 2008
* 2010/0106,174 LANCING DEVICE AND MULTI-LANCET CARTRIDGE 1 2009
 
UNIVERSITY HEALTH NETWORK (2)
9042967 Device and method for wound imaging and monitoring 3 2009
* 2011/0117,025 DEVICE AND METHOD FOR FLUORESCENCE-BASED IMAGING AND MONITORING 36 2009
 
FUJI PHOTO FILM CO., LTD. (5)
* 6151518 Instrument for measuring concentrations of constituent parts of blood 146 1999
* 7599065 Specimen analysis system obtaining characteristic of specimen by diffusion approximation 4 2006
* 7477393 Specimen analysis system obtaining characteristic of specimen by diffusion approximation 1 2006
* 2007/0073,157 Specimen analysis system obtaining characteristic of specimen by diffusion approximation 1 2006
* 2007/0073,158 Specimen analysis system obtaining characteristic of specimen by diffusion approximation 1 2006
 
COVIDIEN LP (3)
6381480 Method and apparatus for monitoring fetal cerebral oxygenation during childbirth 120 2000
7221969 Method and apparatus for determining cerebral oxygen saturation 6 2003
* 2005/0119,542 Method and apparatus for determining cerebral oxygen saturation 1 2003
 
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (1)
6405069 Time-resolved optoacoustic method and system for noninvasive monitoring of glucose 37 1999
 
THE SCHEPEN EYE RESEARCH INSTITUTE (1)
* 6236877 Apparatus for near simultaneous observation of directly scattered image field and multiply scattered image field 10 1998
 
ROCHE DIABETES CARE, INC. (6)
7565249 Method for the determination of a light transport parameter in a biological matrix 0 2002
7315752 Method and device for determining a light transport parameter in a biological matrix 101 2002
* 2005/0002,031 Method and device for determining a light transport parameter in a biological matrix 2 2002
* 2004/0152,089 Method for the determination of a light transport parameter in a biological matrix 1 2004
* 8570519 Method and device for analyzing a body fluid 0 2012
* 2012/0281,219 METHOD AND DEVICE FOR ANALYZING A BODY FLUID 0 2012
 
FOSS ANALYTICAL AB (1)
* 2011/0149,278 OFFSET PROBE 0 2009
 
CRITISENSE LTD. (6)
* 7130672 Apparatus and method for monitoring tissue vitality parameters 17 2001
7313424 Diagnosis of body metabolic emergency state 11 2003
* 2005/0234,315 Diagnosis of body metabolic emergency state 2 2003
* 2004/0054,270 Apparatus and method for monitoring tissue vitality parameters 43 2003
* 2006/0161,055 Probe design 7 2005
* 2007/0179,366 Apparatus and Method for Monitoring Tissue Vitality Parameters 24 2006
 
AVL MEDICAL INSTRUMENTS AG (1)
* 6103197 Method and apparatus for optically determining total hemoglobin concentration 34 1998
 
NATIONAL TSING HUA UNIVERSITY (2)
* 7851251 Portable optical detection chip and manufacturing method thereof 6 2010
* 2010/0240,168 PORTABLE OPTICAL DETECTION CHIP AND MANUFACTURING METHOD THEREOF 0 2010
 
FIBRO CONTROL, INC. (3)
8357176 Fibroid treatment apparatus and method 0 2007
8403953 Balloon with rigid tube for occluding the uterine artery 0 2009
* 2011/0022,073 BALLOON WITH RIGID TUBE FOR OCCLUDING THE UTERINE ARTERY 8 2009
 
NELLCOR PURITAN BENNETT INCORPORATED (1)
* 6115621 Oximetry sensor with offset emitters and detector 132 1997
 
MCC GESELLSCHAFT FUR DIAGNOSESYSTEME IN MEDIZIN UND TECHNIK MBH & CO. KG (2)
* 7095491 Device and method for measuring constituents in blood 10 2003
* 2005/0168,722 Device and method for measuring constituents in blood 46 2003
 
FOVIOPTICS, INC. (7)
6305804 Non-invasive measurement of blood component using retinal imaging 164 2000
6650915 Non-invasive measurement of blood analytes using photodynamics 124 2001
6895264 Non-invasive psychophysical measurement of glucose using photodynamics 127 2003
6889069 Non-invasive measurement of blood analytes using photodynamics 118 2003
* 2004/0147,820 Non-invasive measurement of blood analytes using photodynamics 11 2003
* 2004/0087,843 Non-invasive psychophysical measurement of glucose using photodynamics 15 2003
* 2005/0010,091 Non-invasive measurement of blood glucose using retinal imaging 27 2004
 
ABBOTT LABORATORIES (6)
6662030 Non-invasive sensor having controllable temperature feature 107 1998
6353226 Non-invasive sensor capable of determining optical parameters in a sample having multiple layers 73 1998
6241663 Method for improving non-invasive determination of the concentration of analytes in a biological sample 69 1999
6615061 Optical sensor having a selectable sampling distance for determination of analytes 123 1999
6662031 Method and device for the noninvasive determination of hemoglobin and hematocrit 24 2000
6526298 Method for the non-invasive determination of analytes in a selected volume of tissue 337 2000
 
GLUSENSE LTD. (4)
7951357 Implantable power sources and sensors 3 2005
* 2008/0319,287 Implantable Power Sources and Sensors 1 2005
* 2010/0160,749 IMPLANTABLE OPTICAL GLUCOSE SENSING 3 2008
9037205 Implantable optical glucose sensing 0 2011
 
FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH (1)
* 6821432 Measuring apparatus and a measuring method for the determination of parameters of medical fluids 39 2002
 
ROCHE DIAGNOSTICS GMBH (1)
* 6081734 Monitoring system for the regular intake of a medicament 70 1999
 
GLT ACQUISITION CORP. (14)
7606608 Optical sampling interface system for in-vivo measurement of tissue 20 2004
* 2005/0203,359 Optical sampling interface system for in-vivo measurement of tissue 4 2004
7519406 Noninvasive analyzer sample probe interface method and apparatus 35 2005
7787924 Compact apparatus for noninvasive measurement of glucose through near-infrared spectroscopy 29 2006
* 2006/0173,254 Compact apparatus for noninvasive measurement of glucose through near-infrared spectroscopy 122 2006
* 2006/0195,023 Compact apparatus for noninvasive measurement of glucose through near-infrared spectroscopy 121 2006
* 2006/0183,983 Compact apparatus for noninvasive measurement of glucose through near-infrared spectroscopy 122 2006
7697966 Noninvasive targeting system method and apparatus 36 2006
8504128 Method and apparatus for coupling a channeled sample probe to tissue 45 2008
* 2008/0319,382 METHOD AND APPARATUS FOR COUPLING A CHANNELED SAMPLE PROBE TO TISSUE 4 2008
8868147 Method and apparatus for controlling positioning of a noninvasive analyzer sample probe 39 2008
* 2008/0319,299 METHOD AND APPARATUS FOR CONTROLLING POSITIONING OF A NONINVASIVE ANALYZER SAMPLE PROBE 12 2008
* 2009/0036,759 COLLAPSIBLE NONINVASIVE ANALYZER METHOD AND APPARATUS 9 2008
8718738 Method and apparatus for coupling a sample probe with a sample site 56 2009
 
REVOLUTIONARY BUSINESS CONCEPTS, INC. D/B/A RBC PRODUCT DEVELOPMENT (2)
7884933 Apparatus and method for determining analyte concentrations 2 2010
8199322 Apparatus and method for determining analyte concentrations 3 2011
 
UNIVERSITY OF MASSACHUSETTS (2)
7616303 Systems and methods for correcting optical reflectance measurements 6 2006
8873035 Systems and methods for correcting optical reflectance measurements 0 2011
 
ELSNER, ANN E. (1)
6640124 Imaging apparatus and methods for near simultaneous observation of directly scattered light and multiply scattered light 6 2001
 
UNIVERSITY OF MARYLAND, BALTIMORE (1)
6806089 Low frequency modulation sensors using nanosecond fluorophores 10 2001
 
ABBOTT LABORATORIES (2)
6654620 Method for improving non-invasive determination of the concentration of analytes in a biological sample 42 2001
6630673 Non-invasive sensor capable of determining optical parameters in a sample having multiple layers 50 2001
 
KWALATA TRADING LIMITED (4)
8685724 In vitro techniques for use with stem cells 0 2005
8541232 Composition comprising a progenitor/precursor cell population 1 2007
* 2010/0291,610 Regulating Stem Cells 1 2007
9234173 Regulating stem cells 0 2013
 
OPTISCAN BIOMEDICAL CORPORATION (3)
7006857 Method for determining analyte concentration using periodic temperature modulation and phase detection 109 2003
6944486 Method and apparatus for determining analyte concentration using phase and magnitude detection of a radiation transfer function 113 2003
* 2004/0087,841 Method and apparatus for determining analyte concentration using phase and magnitude detection of a radiation transfer function 10 2003
 
UNIVERSITY OF SOUTHERN CALIFORNIA (2)
* 7611470 Measurement of cardiac output and blood volume by non-invasive detection of indicator dilution 2 2004
* 2005/0020,891 Measurement of cardiac output and blood volume by non-invasive detection of indicator dilution 9 2004
 
SENSYS MEDICAL, INC. (10)
* 7299080 Compact apparatus for noninvasive measurement of glucose through near-infrared spectroscopy 202 2004
* 2005/0020,892 Compact apparatus for noninvasive measurement of glucose through near-infrared spectroscopy 6 2004
* 2005/0159,656 Method and apparatus for presentation of noninvasive glucose concentration information 119 2004
* 2005/0187,439 Sampling interface system for in-vivo estimation of tissue analyte concentration 114 2005
* 2006/0211,931 Noninvasive analyzer sample probe interface method and apparatus 114 2006
* 2006/0217,602 Method and apparatus for noninvasive targeting 28 2006
* 2006/0206,018 Method and apparatus for noninvasive targeting 23 2006
* 2007/0149,868 Method and Apparatus for Photostimulation Enhanced Analyte Property Estimation 21 2006
* 2007/0234,300 Method and Apparatus for Performing State-Table Driven Regression Testing 17 2006
* 2008/0033,275 Method and Apparatus for Sample Probe Movement Control 17 2007
* Cited By Examiner