Method and aparatus for determining an analyte in a biological sample

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 5770454
SERIAL NO

08737135

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Abstract

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A method and apparatus for analytical determination of a concentration of an analyte in a biological sample include a series of hardware elements and method steps which perform at least two detection measurements, with each detection measurement including the step of irradiating light at an irradiation site as primary light into the biological sample through a boundary surface. The light is propagated along a light path, and light is detected as it emerges from the biological sample as secondary light through a detection site. The irradiation site and detection site are separated by a measuring distance. At least two detection measurements are performed with at least two different measurement light paths between the irradiation site and the detection site. Each of the detection measurements is a frequency-domain spectroscopic measurement which is performed at at least two different wavelengths of light, and includes a comparison of a phase shift of the secondary light with the primary light as a first measurement variable, and an intensity of the secondary light as a second measurement variable. The method also includes the steps of determining the analyte concentration based upon the first and second measurement variables.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
BOEHRINGER MANNHEIM GMBHMANNHEIM171

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Boecker, Dirk Heidelberg, DE 138 18541
Essenpreis, Matthias Gauting, DE 27 2767
Haar, Hans-Peter Wiesloch, DE 88 4763
Hein, Heinz-Michael Seeheim-Jugenheim, DE 18 624

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