US Patent No: 5,770,454

Number of patents in Portfolio can not be more than 2000

Method and aparatus for determining an analyte in a biological sample

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Abstract

A method and apparatus for analytical determination of a concentration of an analyte in a biological sample include a series of hardware elements and method steps which perform at least two detection measurements, with each detection measurement including the step of irradiating light at an irradiation site as primary light into the biological sample through a boundary surface. The light is propagated along a light path, and light is detected as it emerges from the biological sample as secondary light through a detection site. The irradiation site and detection site are separated by a measuring distance. At least two detection measurements are performed with at least two different measurement light paths between the irradiation site and the detection site. Each of the detection measurements is a frequency-domain spectroscopic measurement which is performed at at least two different wavelengths of light, and includes a comparison of a phase shift of the secondary light with the primary light as a first measurement variable, and an intensity of the secondary light as a second measurement variable. The method also includes the steps of determining the analyte concentration based upon the first and second measurement variables.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
BOEHRINGER MANNHEIM GMBHMANNHEIM871

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Boecker, Dirk Palo Alto, CA 203 9580
Essenpreis, Matthias Fremont, CA 29 1249
Haar, Hans-Peter Wiesloch, DE 102 2552
Hein, Heinz-Michael Darmstadt, DE 23 346

Cited Art

Patent Info (Count) # Cites Year
 
HAMAMATSU PHOTONICS K.K. (4)
5,441,054 Apparatus for measuring absorption information in scattering medium and method therefor 38 1993
5,477,051 Apparatus for measuring optical information in scattering medium and method therefor 32 1993
5,517,987 Method for measuring internal information in scattering medium and apparatus for the same 44 1994
5,529,065 Method for measuring scattering medium and apparatus for the same 30 1994
 
BOEHRINGER MANNHEIM GMBH (2)
5,551,422 Method and apparatus for analytical determination of glucose in a biological matrix 110 1994
5,507,288 Analytical system for monitoring a substance to be analyzed in patient-blood 533 1995
 
NON-INVASIVE TECHNOLOGY, INC. (1)
4,972,331 Phase modulated spectrophotometry 150 1989
 
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (1)
5,497,769 Photosensor with multiple light sources 49 1993
 
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (1)
5,137,355 Method of imaging a random medium 65 1989
 
WELLS, STEPHEN (1)
5,277,181 Noninvasive measurement of hematocrit and hemoglobin content by differential optical analysis 206 1991

Patent Citation Ranking

Forward Cites

Patent Info (Count) # Cites Year
 
ABBOTT LABORATORIES (9)
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6,615,061 Optical sensor having a selectable sampling distance for determination of analytes 83 1999
7,043,287 Method for modulating light penetration depth in tissue and diagnostic applications using same 110 1999
6,662,031 Method and device for the noninvasive determination of hemoglobin and hematocrit 14 2000
6,526,298 Method for the non-invasive determination of analytes in a selected volume of tissue 189 2000
6,654,620 Method for improving non-invasive determination of the concentration of analytes in a biological sample 32 2001
6,630,673 Non-invasive sensor capable of determining optical parameters in a sample having multiple layers 28 2001
 
CAS MEDICAL SYSTEMS, INC. (7)
6,456,862 Method for non-invasive spectrophotometric blood oxygenation monitoring 100 2001
7,047,054 Laser diode optical transducer assembly for non-invasive spectrophotometric blood oxygenation monitoring 26 2001
7,072,701 Method for spectrophotometric blood oxygenation monitoring 88 2003
8,078,250 Method for spectrophotometric blood oxygenation monitoring 0 2006
7,313,427 Laser diode optical transducer assembly for non-invasive spectrophotometric blood oxygenation 31 2006
8,396,526 Method for spectrophotometric blood oxygenation monitoring 0 2006
8,391,942 Method and apparatus for determining cerebral desaturation in patients undergoing deep hypothermic circulatory arrest 0 2009
 
FACET TECHNOLOGIES, LLC (4)
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7,837,633 Lancing device and multi-lancet cartridge 1 2005
8,298,255 Cap displacement mechanism for lancing device and multi-lancet cartridge 0 2007
8,221,332 Multi-lancet cartridge and lancing device 0 2008
 
FOVIOPTICS, INC. (4)
6,305,804 Non-invasive measurement of blood component using retinal imaging 104 2000
6,650,915 Non-invasive measurement of blood analytes using photodynamics 84 2001
6,895,264 Non-invasive psychophysical measurement of glucose using photodynamics 82 2003
6,889,069 Non-invasive measurement of blood analytes using photodynamics 76 2003
 
GLT ACQUISITION CORP. (4)
7,606,608 Optical sampling interface system for in-vivo measurement of tissue 2 2004
7,519,406 Noninvasive analyzer sample probe interface method and apparatus 3 2005
7,787,924 Compact apparatus for noninvasive measurement of glucose through near-infrared spectroscopy 1 2006
7,697,966 Noninvasive targeting system method and apparatus 0 2006
 
HAMAMATSU PHOTONICS K.K. (4)
5,983,121 Absorption information measuring method and apparatus of scattering medium 12 1997
6,240,305 Method and apparatus for measuring absorption information of a scattering medium 87 1999
6,236,871 Absorption information measuring method and apparatus of scattering medium 80 1999
6,233,470 Absorption information measuring method and apparatus of scattering medium 80 1999
 
FUJI PHOTO FILM CO., LTD. (3)
6,151,518 Instrument for measuring concentrations of constituent parts of blood 107 1999
7,599,065 Specimen analysis system obtaining characteristic of specimen by diffusion approximation 2 2006
7,477,393 Specimen analysis system obtaining characteristic of specimen by diffusion approximation 0 2006
 
COVIDIEN LP (2)
6,381,480 Method and apparatus for monitoring fetal cerebral oxygenation during childbirth 96 2000
7,221,969 Method and apparatus for determining cerebral oxygen saturation 2 2003
 
CRITISENSE LTD. (2)
7,130,672 Apparatus and method for monitoring tissue vitality parameters 8 2001
7,313,424 Diagnosis of body metabolic emergency state 2 2003
 
FIBRO CONTROL, INC. (2)
8,357,176 Fibroid treatment apparatus and method 0 2007
8,403,953 Balloon with rigid tube for occluding the uterine artery 0 2009
 
OPTISCAN BIOMEDICAL CORPORATION (2)
7,006,857 Method for determining analyte concentration using periodic temperature modulation and phase detection 78 2003
6,944,486 Method and apparatus for determining analyte concentration using phase and magnitude detection of a radiation transfer function 82 2003
 
REVOLUTIONARY BUSINESS CONCEPTS, INC. D/B/A RBC PRODUCT DEVELOPMENT (2)
7,884,933 Apparatus and method for determining analyte concentrations 0 2010
8,199,322 Apparatus and method for determining analyte concentrations 0 2011
 
ROCHE DIAGNOSTICS OPERATIONS, INC. (2)
7,565,249 Method for the determination of a light transport parameter in a biological matrix 0 2002
7,315,752 Method and device for determining a light transport parameter in a biological matrix 58 2002
 
AVL MEDICAL INSTRUMENTS AG (1)
6,103,197 Method and apparatus for optically determining total hemoglobin concentration 21 1998
 
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (1)
6,405,069 Time-resolved optoacoustic method and system for noninvasive monitoring of glucose 15 1999
 
FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH (1)
6,821,432 Measuring apparatus and a measuring method for the determination of parameters of medical fluids 9 2002
 
GLUSENSE LTD. (1)
7,951,357 Implantable power sources and sensors 0 2005
 
MCC GESELLSCHAFT FUR DIAGNOSESYSTEME IN MEDIZIN UND TECHNIK MBH & CO. KG (1)
7,095,491 Device and method for measuring constituents in blood 2 2003
 
MINOLTA CO., LTD. (1)
6,847,835 Transcutaneous bilirubin concentration measuring apparatus and a measurement data checking plate for use with the same 15 2000
 
NATIONAL TSING HUA UNIVERSITY (1)
7,851,251 Portable optical detection chip and manufacturing method thereof 0 2010
 
NELLCOR PURITAN BENNETT INCORPORATED (1)
6,115,621 Oximetry sensor with offset emitters and detector 110 1997
 
ROCHE DIAGNOSTICS GMBH (1)
6,081,734 Monitoring system for the regular intake of a medicament 9 1999
 
SCHEPENS EYE RESEARCH INSTITUTE, INC., THE (1)
6,640,124 Imaging apparatus and methods for near simultaneous observation of directly scattered light and multiply scattered light 1 2001
 
SENSYS MEDICAL, INC. (1)
7,299,080 Compact apparatus for noninvasive measurement of glucose through near-infrared spectroscopy 89 2004
 
THE SCHEPEN EYE RESEARCH INSTITUTE (1)
6,236,877 Apparatus for near simultaneous observation of directly scattered image field and multiply scattered image field 5 1998
 
TYCO HEALTHCARE GROUP LP (1)
6,343,223 Oximeter sensor with offset emitters and detector and heating device 99 2000
 
UNIVERSITY OF MARYLAND, BALTIMORE, A CONSTITUTENT INSTITUTION OF THE UNIVERSITY SYSTEM OF MARYLAND (1)
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UNIVERSITY OF MASSACHUSETTS (1)
7,616,303 Systems and methods for correcting optical reflectance measurements 0 2006
 
UNIVERSITY OF SOUTHERN CALIFORNIA (1)
7,611,470 Measurement of cardiac output and blood volume by non-invasive detection of indicator dilution 1 2004