Synthesis of carbodimide analogs of chlorins and bacteriochlorins and their use for diagnosis and treatment of cancer
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United States of America Patent
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Jun 23, 1998
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N/A
app pub date -
Mar 8, 1996
filing date -
Mar 8, 1996
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Abstract
A method for the preparation of an imide derivative of purpurin by reacting hexylamine with a chlorin or bacteriochlorin having a macrocycle with a six-membered anhydride ring fused thereto, said macrocycle containing a and b rings which may be saturated or unsaturated at R.sub.4 to R.sub.11 positions of the rings and which R.sub.4 and R.sub.11, positions may contain at least one group selected from the group consisting of hydrogen, hydroxy, formyl, substituted and unsubstituted alkyl, alkoxy, alkenyl, aryl and aryloxy wherein carbon containing groups may be substituted with a substituent selected from, hydroxy, phosphoro, carboxy, halo, sulfo, amino and ether, to obtain a purpurin derivative; and reacting the purpurin derivative with a carbodiimide to obtain the imide derivative of purpurin. The invention further includes novel imides made by the method.
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