Methods for detection by in situ hybridization of multiple chromosomes or regions thereof
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United States of America Patent
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Jul 7, 1998
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app pub date -
Jan 10, 1997
filing date -
Sep 20, 1990
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Abstract
Direct label probe compositions which stain DNA of a preselected single chromosome or region of a chromosome of a multi-chromosomal genome are provided that comprise mixed DNA segments which are covalently bound to fluorophore groups through linking groups. The mixed DNA segments are derived from the DNA present in the preselected chromosome or chromosome region. These probe compositions can be used concurrently or sequentially with other probe compositions.
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