Ultraselective opioidmimetic peptides and pharmacological and therapeutic uses thereof

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United States of America Patent

PATENT NO 5780589
SERIAL NO

08347531

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Abstract

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Novel opioidmimetic dipeptides, tripeptides and cyclic peptides exhibit enhanced affinity and selectivity for .delta. opioid receptors. The peptides are represented by the formulas L/D-Dmt-L-/D-Tic-R', L/D-Dmt-L-/D-Tic-R-R' and cyclic (L/D-Dmt-L/D-Tic) wherein Dmt is 2',6',-dimethyl-L/D-tyrosine Tic is L-/D-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, R is a natural or unusual aliphatic amino residue and R' is a functional group at the carboxyl terminus of the peptide. Pharmacological and therapeutic and compositions are also provided.

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Patent Owner(s)

Patent OwnerAddress
HEALTH AND HUMAN SERVICES DEPARTMENT OF UNITED STATES OF AMERICA THEWASHINGTON DC 20201

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Lazarus, Lawrence H Durham, NC 6 26
Salvadori, Severo Ferrara, IT 7 27
Temussi, Piero Andrea Naples, IT 1 19

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