Antisense oligomers
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United States of America Patent
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Jul 14, 1998
Grant Date -
N/A
app pub date -
Oct 8, 1996
filing date -
Oct 13, 1995
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
Antisense oligomers of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.4 are independently hydrogen, lower alkyl or acyl; R.sub.3 is hydrogen or lower alkyl; B is a nucleobase or a protected nucleobase, such that said oligomer has a sequence of bases complementary to a selected RNA; n is 5 to 30; X is NR.sub.3 R.sub.4 ; Y is OR.sub.3, or NHR.sub.3 ; as well as, pharmaceutically acceptable salts thereof.
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