Monoclonal antibody 369.2B specific for .beta. A4 peptide
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United States of America Patent
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Jul 28, 1998
Grant Date -
N/A
app pub date -
Feb 14, 1995
filing date -
Feb 14, 1995
priority date (Note) -
Expired
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Abstract
The instant invention provides for monoclonal antibody which is specific for the .beta.A4 peptide, and in particular the free C-terminus of .beta.A4 '1-42' but not '1-43', and stains diffuse and fibrillar amyloid, vascular amyloid, and neurofibrillary tangles. The instant invention further provides for antibody fragments and constructs thereof which have the same binding specificity. The instant invention also provides for methods of diagnosis, screening and therapeutics for treating unique forms of .beta.A4 peptide, using the antibodies of the instant invention.
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