Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor

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United States of America Patent

PATENT NO 5789184
SERIAL NO

08464531

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Abstract

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Yeast cells are engineered to express both a surrogate of a pheromone system protein (e.g., enzymes involved in maturation of .alpha.-factor, transporters of a-factor, pheromone receptors, etc.) and a potential peptide modulator of the surrogate, in such a manner that the inhibition or activation of the surrogate affects a screenable or selectable trait of the yeast cells. Various additional features improve the signal-to-noise ratio of the screening/selection system.

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Patent Owner(s)

Patent OwnerAddress
CADUS TECHNOLOGIES INC767 FIFTH AVENUE NEW YORK NY 10153

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Broach, Jim Princeton, NJ 7 107
Fowlkes, Dana M Chapel Hill, NC 36 457
Klein, Christine Ossining, NY 12 130
Manfredi, John Ossining, NY 32 248
Murphy, Andrew J Montclair, NJ 509 7038
Paul, Jeremy South Nyack, NY 12 153
Trueheart, Joshua South Nyack, NY 59 493

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