Antisense inhibition of ICAM-1, E-selectin, and CMV IE1/IE2

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United States of America Patent

PATENT NO 5789573
SERIAL NO

08653653

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Abstract

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Compositions and methods are provided for inhibiting the translation of a capped target mRNA. Antisense oligomers of the invention are targeted to the 5' cap region of the target mRNA and include oligonucleosides, PNAs, or oligonucleotides modified at the 2' position of the sugar. Preferably said oligomers inhibit protein translation directly via interference with ribosome assembly.

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Patent Owner(s)

Patent OwnerAddress
ISIS PHARMACEUTICALS INC1896 RUTHERFORD ROAD CARLSBAD CA 92008

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Anderson, Kevin P Carlsbad, CA 23 820
Baker, Brenda Carlsbad, CA 10 346
Bennett, C Frank Carlsbad, CA 412 7677

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