Mutant diphtheria toxin conjugates
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United States of America Patent
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Aug 11, 1998
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app pub date -
Oct 17, 1994
filing date -
Oct 5, 1987
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Abstract
A potent and specific immunotoxin is prepared by coupling an inactivated diphtheria toxin to a binding moiety such as a monoclonal antibody or transferrin. The immunotoxins are specific for human tumors and leukemias and are indistinguishable in cell toxicity from that of the native toxin linked to the binding domain without the toxicity to other cells. The immunotoxin is useful in treating graft versus host disease as well as selectively killing tumor cells, such as medulloblastoma and glioblastoma cells.
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