Method for obtaining RNA aptamers based on shape selection
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United States of America Patent
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Aug 11, 1998
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N/A
app pub date -
Jun 12, 1996
filing date -
Jun 12, 1996
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Abstract
RNA molecules are selected from a random sequence library for their ability to bind to a selecting nucleic acid structural element. Selection of RNA aptamers with extensive Watson-Crick complementarity to the nucleic acid ligand is precluded by inclusion of a blocking oligodeoxynucleotide in the binding phase of the selection protocol.
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