Cloning and expression of human islet glutamic acid decarboxylase autoantigen
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United States of America Patent
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Aug 11, 1998
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N/A
app pub date -
Aug 17, 1993
filing date -
May 15, 1991
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Abstract
Human pancreatic islet cell glutamic acid decarboxylase (GAD), an autoantigen involved in the development of insulin-dependent diabetes mellitus (IDDM), has been cloned, sequenced and expressed by recombinant means. Recombinant human islet cell GAD polypeptides and antibodies specific to the GAD polypeptides can be used in methods of diagnosis and treatment, including use in immunoadsorptive therapy and the induction of immune tolerance.
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