Kallikrein-inhibiting "kunitz domain" proteins and analogues thereof
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United States of America Patent
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Aug 18, 1998
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app pub date -
Sep 25, 1996
filing date -
Jan 11, 1994
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Abstract
Proteins are disclosed that are homologous to bovine pancreatic trypsin inhibitor (BPTI) Kunitz domains, and especially proteins that are homologous to lipoprotein-associated coagulation inhibitor (LACI) Kunitz domains, which inhibit one or more plasma and/or tissue kallikreins, and uses of such proteins in therapeutic and diagnostic methods also are disclosed. In particular, Kunitz domains derived from Kunitz domains of human origin and especially to the first Kunitz domain of LACI are disclosed.
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