Method for selectively purging CD77+ cells from bone marrow

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United States of America Patent

PATENT NO 5801145
SERIAL NO

08599211

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Abstract

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A method for the selective purging ex vivo of CD77 positive cells from bone marrow prior to autologous transplantation is described. The method involves treating the bone marrow with shiga toxin or shiga-like toxin-1 to kill CD77.sup.+ cells or to remove them by affinity chromatography. The toxin selectively binds to CD77.sup.+ cells and not to other bone marrow cells. The method offers a means for curing non-Hodgkin's lymphomas.

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Patent OwnerAddress
ONTARIO CANCER INSTITUTE THE500 SHERBOURNE STREET TORONTO M4X 1K9

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gariepy, Jean Toronto, CA 14 105

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