Manufacturing matrices
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United States of America Patent
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-
Sep 8, 1998
Grant Date -
N/A
app pub date -
Oct 11, 1995
filing date -
Apr 14, 1993
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
Porous cellulose matrices with a defined particle size and a significantly higher porosity (i.e. pore volume) than conventional formulations, such as pellet formulations containing cellulose and binders are prepared. The cellulose is mechanically treated with low adhesion to the process equipment during a controlled gradual addition of an aqueous based fluid, optionally containing a surface-active ingredient, into regular particles, which are finally dried to obtain dry porous cellulose matrices. The so obtained matrices can be used as carriers for bioactive substances in multiple-unit preparations or tablets.
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