High level of expression of ingap in bacterial and euraryotic cells
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United States of America Patent
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Sep 8, 1998
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Aug 12, 1997
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Oct 30, 1996
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Abstract
Removal of the nucleotide sequence encoding the signal peptide from the INGAP coding sequence allows cultured cells to express substantial amounts of INGAP activity. Previous attempts have provided only low yields of INGAP, possibly because the signal sequence of INGAP is toxic to the cells.
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