US Patent No: 5,804,594

Number of patents in Portfolio can not be more than 2000

Pharmaceutical compositions and methods for improving wrinkles and other skin conditions

Stats

ATTORNEY / AGENT: (SPONSORED)

Importance

Loading Importance Indicators... loading....

Abstract

See full text

This application relates to a pharmaceutical composition for the prevention and treatment of skin conditions in a patient having a sugar compound that is converted to a glycosaminoglycan in the patient in an amount sufficient to thicken the skin, a primary antioxidant component in an amount sufficient to substantially inhibit the formation of collagenase and elastase, at least one amino acid component in an amount sufficient to assist in the thickening of the skin, and at least one transition metal component in an amount effective to bind collagen and elastic fibers and rebuild skin. In one preferred form, the composition further includes a catechin-based preparation, a glucosamine or a pharmaceutically acceptable salt or ester thereof, and a chondroitin or a pharmaceutically acceptable salt or ester thereof. In a more preferred form, the invention further includes a vitamin E source, a cysteine source, a vitamin B.sub.3 source, quercetin dihydrate, pyridoxal 5 phosphate-Co B.sub.6, a methionine source, and a vitamin A source. The invention further relates to a method for the prevention or treatment of skin conditions by administering the pharmaceutical composition in an amount therapeutically effective to modify the thickness of the skin to prevent or treat at least one skin condition.

Loading the Abstract Image... loading....

First Claim

See full text

Family

Loading Family data... loading....

Patent Owner(s)

Patent OwnerAddressTotal Patents
UNILEVER NV3013 AL ROTTERDAM18

International Classification(s)

  • [Classification Symbol]
  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Murad, Howard 4316 Marina City Dr., Marina del Rey, CA 90292 34 842

Cited Art Landscape

Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (2)
* 4,424,232 Treatment of herpes simplex 21 1982
* 5,281,196 Skin treatment composition and method of use 19 1992
 
Bioderm, Inc. (2)
* 4,647,453 Treatment for tissue degenerative inflammatory disease 63 1985
* 4,938,969 Method for the treatment of aging or photo-damaged skin 49 1988
 
WOUNDCARE ACQUISITION LLC (1)
* 4,414,202 Composition for treatment of wounds 39 1981
 
ROTTA RESEARCH LABORATORIUM S.P.A. (1)
* 4,642,340 Stable compounds of glucosamine sulphate 23 1982
 
AMRAD RESEARCH AND DEVELOPMENT, AN ISRAELI LIMITED PARTNERSHIP (1)
* 5,162,303 Pharmaceutical compositions containing prolactin and methods for the use thereof 9 1990
 
UNION BANK (1)
* 4,486,416 Protection of human and animal cells subject to exposure to trauma 39 1981
 
Redken Laboratories, Inc. (1)
* 4,518,614 Cosmetic preparation 18 1983
 
BIOMATRIX, INC. (1)
* 5,153,174 Polymer mixtures useful in skin care 35 1989
 
SHISEIDO COMPANY, LTD. (1)
* 5,415,875 Anti-peroxide external preparation for skin 18 1993
 
PROFESSIONAL DIETETICS S.R.L. (1)
* 5,198,465 Compositions based on amino acids for preventing and treating precursor deficiencies in the synthesis of collagen 37 1991
 
TEXTILE RESEARCH INSTITUTE INC. (1)
* 5,296,500 Use of N-acetyl-cysteine and derivatives for regulating skin wrinkles and/or skin atrophy 47 1993
 
Nutramax Laboratories, Inc. (2)
* 5,364,845 Glucosamine, chondroitin and manganese composition for the protection and repair of connective tissue 73 1993
* 5,587,363 Aminosugar and glycosaminoglycan composition for the treatment and repair of connective tissue 77 1994
 
METABOLIC TECHNOLOGIES, INC. (2)
* 5,308,627 Nutritional supplement for optimizing cellular health 36 1992
* 5,332,579 Nutritional supplement for optimizing cellular health 46 1992
 
Senetek PLC (1)
* 5,371,089 Method and composition for ameliorating the adverse effects of aging 17 1994
 
Seikagaku Kogyo Co., Ltd. (1)
* 4,716,224 Crosslinked hyaluronic acid and its use 80 1985
 
SOCIETE ANONYME : SANOFI, A FRENCH CORP. OF FRANCE (1)
* 4,956,173 Composition and use of ademetionine against ageing of the skin 23 1988
* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
Bioderm, Inc. (7)
* 6,217,914 Ascorbic acid composition and method for treatment of aging or damaged skin 19 1999
6,444,699 Method for treatment of aging or damage skin 12 2000
* 8,003,134 Ascorbic acid composition and method for treatment of aging or damaged skin 0 2001
* 7,816,402 Compositions and methods for the treatment of skin 0 2001
* 2002/0037,314 Compositions and methods 5 2001
7,670,620 Topical composition for the treatment of psoriasis and related skin disorders 1 2002
7,834,055 Compositions and methods for the treatment of skin 0 2008
 
Other [Check patent profile for assignment information] (24)
* 2002/0031,557 Ascorbic acid composition and method for treatment of aging or damaged skin 11 2001
* 6,641,806 Proteoglycan compositions for treating arthritic inflammatory conditions 3 2002
* 6,624,148 Proteoglycan compositions for treatment of cardiovascular inflammatory diseases 3 2002
* 2004/0005,355 Proteoglycan compositions for treatment of inflammatory diseases 2 2003
* 2005/0003,023 Topical composition for the treatment of psoriasis and related skin disorders 6 2003
* 2004/0230,559 Information processing device and information processing method 20 2004
* 2004/0192,649 Skin care compositions containing a sugar amine 5 2004
* 2005/0043,274 Pharmaceutical compositions and methods for lowering blood pressure and pulse rate 3 2004
* 7,482,026 Compositions and methods directed towards sore muscles and joints 0 2004
* 2005/0025,840 Compositions and methods directed towards sore muscles and joints 8 2004
* 2005/0147,675 Composition for the treatment and prevention of endothelial dysfunction 6 2005
* 2005/0261,367 Methods for treating dermatological and other health-related conditions in a patient 6 2005
* 2006/0165,819 Topical composition for the treatment of psoriasis and related skin disorders 4 2006
* 2006/0193,809 Skin care compositions containing a sugar amine cross reference to related application 3 2006
* 2006/0188,462 Skin care compositions containing a sugar amine 7 2006
* 2006/0188,467 Skin care composition containing a sugar amine 3 2006
* 7,494,674 Nutraceutical with tart cherries and method of treatment therewith 0 2006
* 2007/0142,270 Aryl Sulfonic Pyridoxines as Antiplatelet Agents 5 2007
* 2008/0125,395 COMPOSITIONS AND METHODS FOR THE TREATMENT OF SKIN 1 2008
7,871,609 Supplements for pain management 2 2008
* 2008/0213,246 Supplements For Pain Management 3 2008
* 2011/0183,018 Cholesterol Sulfate And Amino Sugar Compositions For Enhancement Of Stratum Corneum Function 0 2009
* 2010/0247,692 Cholesterol Sulfate And Amino Sugar Compositions For Enhancement Of Stratum Corneum Function 0 2009
* RE44302 N-acetyl aldosamines, N-acetylamino acids and related N-acetyl compounds and their topical use 0 2010
 
Color Access, Inc. (1)
* 2002/0142,013 Cholesterol sulfate and amino sugar compositions for enhancement of stratum corneum function 3 2001
 
NATUROPATHIC LABORATORIES INTERNATIONAL, INC. (1)
6,482,401 Composition for the relief of joint pain and myofascial pain and method of preparing same 2 1999
 
HEALTH OPTIONS, INC. (1)
* 6,333,304 Therapeutic compositions containing glucosamine, collagen and a bioflavanol for repair and maintenance of connective tissue 16 1999
 
LABORATOIRES PHARMASCIENCE (1)
* 2004/0180,033 Cosmetic method for preventing and/or treating skin stretchmarks, and use in dermatology 1 2004
 
UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC. (2)
7,332,152 Cosmetic composition 1 2004
* 2005/0100,517 Cosmetic composition 18 2004
 
UNIVERSITY TECHNOLOGY CORPORATION (1)
* 6,489,308 Inhibitors of serine protease activity, methods and compositions for treatment of nitric-oxide-induced clinical conditions 17 2000
 
Medicore, Inc. (1)
6,339,085 Therapeutics for cardiovascular and related diseases 19 2000
 
METAGENICS, INC. (3)
6,534,086 Composition and method for treatment of inflammation and pain in mammals 15 2000
6,949,260 Method for treatment of inflammation and pain in mammals 6 2003
* 2003/0185,907 Method for treatment of inflammation and pain in mammals 0 2003
 
LABORATOIRES INNEOV (1)
* 2010/0323,984 COSMETIC ORAL AND/OR PARENTERAL USE OF GLUCOSAMINE OPTIONALLY IN COMBINATION WITH AT LEAST ONE POLYPHENOL COMPOUND, AND CORRESPONDING COMPOSITION 0 2007
 
Ocular Technology Inc. (1)
7,282,225 Composition and methods for improving retinal health 10 2006
 
BIO HOLDING, INC. (2)
* 2007/0224,671 Inhibitors of serine protease activity methods and compositions for treatment of nitric oxide-induced clinical conditions 8 2003
* 2008/0051,330 Inhibitors of serine protease activity, methods and compositions for treatment of herpes viruses 0 2006
 
Advanced Medical Instruments (4)
6,346,519 Method and composition for treating arthritis 39 1999
6,573,299 Method and compositions for treatment of the aging eye 52 1999
* 7,846,914 Composition for the treatment and prevention of endothelial dysfunction 10 2005
* 8,486,889 Composition and method for the treatment and prevention of endothelial dysfunction 0 2012
 
DERMENA NORTH AMERICA, INC. (1)
* 2008/0227,831 FOOD EXTRACTS FOR TREATMENT OF LIPOPROTEIN ABNORMALITIES AND SKIN DISEASES AND SKIN DISORDERS 4 2007
 
Dermena (1)
* 2008/0112,968 NICOTINAMIDE COMPOSITIONS FOR TREATMENT OF SKIN DISEASES AND DISORDERS 0 2007
 
ASTION DEVELOPMENT A/S (1)
* 2003/0105,034 Pyridine carboxy derivatives and an aminosugar 0 2002
 
BONNE BELL, INC. (1)
* 2003/0161,851 Cosmetic lip product with sour flavor 2 2003
 
ARCH Development Corporation (1)
6,576,660 Methods and compositions for regulation of 5-.alpha.-reductase activity 54 2000
 
MARKWINS BEAUTY PRODUCTS, INC. (1)
6,723,307 Cosmetic lip product with sour flavor 0 2002
 
Motion Potion, Inc. (1)
* 2005/0113,287 Composition to enhance joint function and repair 3 2004
 
MEDICURE INC. (2)
6,489,345 Treatment of diabetes and related pathologies 9 2000
* 2004/0235,907 Treatment of diabetes and related pathologies 5 2004
 
MERRILL LYNCH CAPITAL CANADA INC. (2)
7,148,233 Treatment of cardiovascular and related pathologies 5 2003
7,144,892 Treatment of cardiovascular and related pathologies 5 2003
 
ChronoRX, LLC (3)
* 6,231,889 Unit dosage forms for the treatment of herpes simplex 13 1999
6,632,445 Unit dosage forms for the treatment of herpes simplex 7 2002
* 7,351,715 Unit dosage forms for the treatment of herpes simplex 5 2003
 
Matrix Design (3)
* 6,808,707 Wound healing compositions and methods using tropoelastin and lysyl oxidase 15 2000
* 2002/0150,564 Wound healing compositions and methods using tropoelastin and lysyl oxidase 2 2000
* 2008/0038,243 WOUND HEALING COMPOSITIONS AND METHODS USING TROPOELASTIN AND LYSYL OXIDASE 0 2007
 
Theta Biomedical Consulting & Development Co., Inc. (17)
* 6,984,667 Synergistic proteoglycan compositions for inflammatory conditions 7 2001
* 2002/0176,902 Synergistic proteoglycan compositions for treatment of inflammatory diseases 2 2001
7,799,766 Composition for treating hormonally-dependent cancers 0 2004
* 2004/0180,106 Proteoglycan compositions for treatment of inflammator diseases 3 2004
7,906,153 Anti-inflammatory compositions for treating multiple sclerosis 9 2005
* 2006/0013,905 Anti-inflammatory compositions for treating multiple sclerosis 12 2005
7,759,307 Compositions for protection against superficial vasodilator flush syndrome, and methods of use 0 2007
* 2007/0141,187 Compositions for protection against superficial vasodilator flush syndrome, and methods of use 7 2007
* 2008/0153,761 Compositions for protection against superficial vasodilator flush syndrome, and methods of use 2 2007
7,923,043 Method for protecting humans against superficial vasodilator flush syndrome 0 2008
* 2009/0148,543 Method for protecting humans against superficial vasodilator flush syndrome, 2 2008
9,176,146 Methods of treating autism spectrum disorders and compositions for same 0 2009
* 2011/0027,397 METHODS OF TREATING AUTISM SPECTRUM DISORDERS AND COMPOSITIONS FOR SAME 3 2009
8,268,365 Anti-inflammatory compositions for treating brain inflammation 0 2010
* 2011/0044,944 ANTI-INFLAMMATORY COMPOSITIONS FOR TREATING BRAIN INFLAMMATION 0 2010
9,050,275 Methods of screening for and treating autism spectrum disorders and compositions for same 0 2011
* 2011/0183,019 METHODS OF SCREENING FOR AND TREATING AUTISM SPECTRUM DISORDERS AND COMPOSITIONS FOR SAME 3 2011
 
MEDICURE INTERNATIONAL INC. (33)
6,677,356 Treatment of cardiovascular and related pathologies 15 2000
6,605,612 Cardioprotective phosohonates and malonates 5 2001
6,586,414 Treatment of cerebrovascular disease 16 2001
6,417,204 Pyridoxine AMD pyridoxal analogues: cardiovascular therapeutics 9 2001
6,548,519 Pyridoxine and pyridoxal analogues: novel uses 9 2002
6,861,439 Treatment of cerebrovascular disease 6 2002
7,105,673 Cardioprotective phosphonates and malonates 5 2002
6,780,997 Cardioprotective phosphonates and malonates 7 2002
6,667,315 Cardioprotective phosphonates and malonates 5 2002
6,867,215 Cardioprotective phosphonates and malonates 5 2003
6,897,228 Pyridoxine and pyridoxal analogues: new uses 5 2003
* 2004/0010,015 Pyridoxine and pyridoxal analogues: new uses 1 2003
7,132,430 Treatment of cardiovascular and related pathologies 5 2003
7,125,889 Treating of cardiovascular and related pathologies 5 2003
7,115,625 Treatment of cardiovascular and related pathologies 7 2003
7,115,626 Treatment of cardiovascular and related pathologies 5 2003
* 2004/0038,945 Treatment of cardiovascular and related pathologies 0 2003
* 2004/0033,992 Treatment of cardiovascular and related pathologies 0 2003
* 2004/0033,993 Treatment of cardiovascular and related pathologies 0 2003
* 2004/0033,990 Treatment of cardiovascular and related pathologies 0 2003
* 2004/0033,989 Treatment of cardiovascular and related pathologies 0 2003
* 2004/0121,988 Treatment of cerebrovascular disease 5 2003
7,442,689 Cardioprotective phosphonates and malonates 0 2003
* 2004/0171,588 Cardioprotective phosphonates and malonates 0 2003
* 2006/0241,083 Novel heteroaryl phosphonates as cardioprotective agents 5 2004
7,459,468 Aryl sulfonic pyridoxines as antiplatelet agents 1 2004
* 2006/0094,748 Aryl sulfonic pyridoxines as antiplatelet agents 0 2004
7,425,570 Pyridoxine and pyridoxal analogues: new uses 0 2004
* 2005/0107,443 Pyridoxine and pyridoxal analogues: new uses 0 2004
7,812,037 Dual antiplatelet/anticoagulant pyridoxine analogs 0 2005
* 2006/0094,761 Dual antiplatelet/anticoagulant pyridoxine analogs 8 2005
* 2007/0060,549 COMBINATION THERAPIES EMPLOYING ACE INHIBITORS AND USES THEREOF FOR THE TREATMENT OF DIABETIC DISORDERS 5 2006
* 2008/0306,108 Substituted Pyridoxines As Anti-Platelet Agents 0 2008
 
THE REGENTS OF THE UNIVERSITY OF MICHIGAN (1)
* 2008/0070,874 Compositions and methods for use against acne-induced inflammation and dermal matrix-degrading enzymes 0 2007
 
L'OREAL (2)
* 6,753,000 Hydroxystilbene/ascorbic acid compositions for treating skin afflictions 38 2002
* 2005/0119,539 System for analyzing the skin 4 2004
 
KYOWA HAKKO BIO CO., LTD. (1)
* 2003/0211,183 Skin-improving agent 2 2003
 
Medestea Internazionale SRL (2)
* 7,261,908 Composition based on natural substances useful in the maintenance of the correct hydration of the skin 0 2004
* 2005/0089,501 Composition based on natural substances useful in the maintenance of the correct hydration of the skin 5 2004
 
BOTICA COMERCIAL FARMACEUTICA LTDA. (2)
7,576,045 Use of vinic alcohol in personal care products, cosmetics and perfumes 0 2005
* 2005/0276,775 Use of vinic alcohol in personal care products, cosmetics and perfumes 0 2005
 
The Procter & Gamble Company (7)
6,224,888 Cosmetic compositions 60 1999
6,455,055 Cosmetic compositions 5 1999
6,309,657 Cosmetic compositions 4 1999
6,528,071 Cosmetic compositions 12 2001
* 2002/0182,237 Skin care compositions containing a sugar amine 10 2002
* 2004/0258,645 Means for improving the appearance of mammalian keratinous tissue 6 2004
* 2005/0123,500 Means for improving the appearance of mammalian hair and nails 3 2004
 
Tristrata, Inc. (3)
* RE41339 N-acetyl aldosamines, N-acetylamino acids and related N-acetyl compounds and their topical use 6 2006
* RE41278 N-acetyl aldosamines and related N-acetyl compounds, and their topical use 4 2006
* RE42902 N-acetyl aldosamines, N-acetylamino acids and related N-acetyl compounds and their topical use 1 2009
 
KYOWA HAKKO KOGYO CO., LTD. (1)
* 6,685,970 Compositions containing proanthocyanidin and a vitamin B6 derivative or a salt thereof 2 2000
 
LOTUS PHARMACEUTICAL CO., LTD. (1)
* 2006/0222,689 Skin care compositions and methods 0 2006
 
LABORATOIRES EXPANSCIENCE (1)
* 8,466,109 Cosmetic method for preventing and/or treating skin stretchmarks, and use in dermatology 0 2004
 
Yaizu Suisankagaku Industry Co. Ltd. (1)
* 6,919,306 Method of skin care 0 2002
 
QUERCEGEN PHARMA LLC (10)
7,745,486 Quercetin-containing compositions 2 2007
7,745,487 Method for enhancing physical performance or immune system recovery from intense physical excercise with quercetin-containing compositions 1 2007
* 2008/0032,987 QUERCETIN-CONTAINING COMPOSITIONS 2 2007
* 2008/0015,247 QUERCETIN-CONTAINING COMPOSITIONS 3 2007
8,574,619 Reducing cholesterol levels with combined use of quercetin and statin 0 2008
8,202,900 Method for stabilizing quercetin 1 2008
8,044,096 Method for treating addiction using quercetin-containing compositions 0 2009
8,440,704 Quercetin-containing compositions 0 2009
8,901,109 Quercetin-containing compositions 0 2010
8,507,548 Method for treating addiction using quercetin-containing compositions 0 2011
 
University of Manitoba (3)
* 6,043,259 Treatment of cardiovascular and related pathologies 36 1999
6,890,943 Pyridoxal analogues and methods of treatment 10 2001
7,230,009 Pyridoxal analogues and methods of treatment 10 2003
 
Nutriex, L.L.C. (1)
6,579,544 Method for supplementing the diet 63 2000
 
KAO CORPORATION (1)
* 2008/0269,168 WRINKLE-DIMINISHING AGENT 0 2008
 
REXAL SUNDOWN, INC. (1)
6,358,526 Method of making tablets and tablet compositions produced therefrom 15 2000
 
THE UNIVERSITY OF CHICAGO (2)
6,696,484 Method and compositions for regulation of 5-alpha reductase activity 24 2002
* 2003/0144,346 Methods and compositions for regulation of 5-alpha reductase activity 8 2002
 
VECTURA LIMITED (1)
7,928,089 Mucoactive agents for treating a pulmonary disease 8 2004
 
PHARMACIA CORPORATION (1)
* 2003/0114,416 Method and compositions for the treatment and prevention of pain and inflammation with a cyclooxygenase-2 selective inhibitor and chondroitin sulfate 7 2002
 
UNILEVER NV (3)
* 5,962,517 Pharmaceutical compositions and methods for treating acne 43 1998
7,452,527 Methods of promoting hair growth 7 2003
8,318,140 Methods for promoting hair growth 0 2008
 
HenKan Pharmaceutical Co., Ltd. (2)
7,655,255 Topical composition for transdermal administration 0 2004
* 2004/0228,908 Topical composition for transdermal administration 8 2004
* Cited By Examiner