US Patent No: 5,804,594

Number of patents in Portfolio can not be more than 2000

Pharmaceutical compositions and methods for improving wrinkles and other skin conditions

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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This application relates to a pharmaceutical composition for the prevention and treatment of skin conditions in a patient having a sugar compound that is converted to a glycosaminoglycan in the patient in an amount sufficient to thicken the skin, a primary antioxidant component in an amount sufficient to substantially inhibit the formation of collagenase and elastase, at least one amino acid component in an amount sufficient to assist in the thickening of the skin, and at least one transition metal component in an amount effective to bind collagen and elastic fibers and rebuild skin. In one preferred form, the composition further includes a catechin-based preparation, a glucosamine or a pharmaceutically acceptable salt or ester thereof, and a chondroitin or a pharmaceutically acceptable salt or ester thereof. In a more preferred form, the invention further includes a vitamin E source, a cysteine source, a vitamin B.sub.3 source, quercetin dihydrate, pyridoxal 5 phosphate-Co B.sub.6, a methionine source, and a vitamin A source. The invention further relates to a method for the prevention or treatment of skin conditions by administering the pharmaceutical composition in an amount therapeutically effective to modify the thickness of the skin to prevent or treat at least one skin condition.

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First Claim

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Patent Owner(s)

  • Assignment data not available. Check USPTO

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Murad, Howard Marina del Ray, CA 36 656

Cited Art Landscape

Patent Info (Count) # Cites Year
 
BIODERM, INC. (2)
4,647,453 Treatment for tissue degenerative inflammatory disease 63 1985
4,938,969 Method for the treatment of aging or photo-damaged skin 44 1988
 
METABOLIC TECHNOLOGIES, INC. (2)
5,308,627 Nutritional supplement for optimizing cellular health 36 1992
5,332,579 Nutritional supplement for optimizing cellular health 46 1992
 
NUTRAMAX LABORATORIES, INC. (2)
5,364,845 Glucosamine, chondroitin and manganese composition for the protection and repair of connective tissue 70 1993
5,587,363 Aminosugar and glycosaminoglycan composition for the treatment and repair of connective tissue 70 1994
 
AMRAD RESEARCH AND DEVELOPMENT, AN ISRAELI LIMITED PARTNERSHIP (1)
5,162,303 Pharmaceutical compositions containing prolactin and methods for the use thereof 9 1990
 
BIOMATRIX, INC. (1)
5,153,174 Polymer mixtures useful in skin care 34 1989
 
Continental Pharma (1)
4,285,964 Salts of (+)-catechine, their preparation and use, and compositions containing these salts 9 1979
 
PROFESSIONAL DIETETICS S.R.L. (1)
5,198,465 Compositions based on amino acids for preventing and treating precursor deficiencies in the synthesis of collagen 33 1991
 
REDKEN LABORATORIES, INC. (1)
4,518,614 Cosmetic preparation 18 1983
 
ROTTA RESEARCH LABORATORIUM S.P.A. (1)
4,642,340 Stable compounds of glucosamine sulphate 23 1982
 
Seikagaku Kogyo Co., Ltd. (1)
4,716,224 Crosslinked hyaluronic acid and its use 78 1985
 
SENETEK PLC (1)
5,371,089 Method and composition for ameliorating the adverse effects of aging 16 1994
 
SHISEIDO COMPANY, LTD. (1)
5,415,875 Anti-peroxide external preparation for skin 18 1993
 
SOCIETE ANONYME : SANOFI, A FRENCH CORP. OF FRANCE (1)
4,956,173 Composition and use of ademetionine against ageing of the skin 22 1988
 
TEXTILE RESEARCH INSTITUTE INC. (1)
5,296,500 Use of N-acetyl-cysteine and derivatives for regulating skin wrinkles and/or skin atrophy 43 1993
 
UNION BANK (1)
4,486,416 Protection of human and animal cells subject to exposure to trauma 38 1981
 
WOUNDCARE ACQUISITION LLC (1)
4,414,202 Composition for treatment of wounds 38 1981
 
Other [Check patent profile for assignment information] (2)
4,424,232 Treatment of herpes simplex 20 1982
5,281,196 Skin treatment composition and method of use 18 1992

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
MEDICURE INTERNATIONAL INC. (19)
6,677,356 Treatment of cardiovascular and related pathologies 13 2000
6,605,612 Cardioprotective phosohonates and malonates 5 2001
6,586,414 Treatment of cerebrovascular disease 11 2001
6,417,204 Pyridoxine AMD pyridoxal analogues: cardiovascular therapeutics 9 2001
6,548,519 Pyridoxine and pyridoxal analogues: novel uses 9 2002
6,861,439 Treatment of cerebrovascular disease 6 2002
7,105,673 Cardioprotective phosphonates and malonates 5 2002
6,780,997 Cardioprotective phosphonates and malonates 7 2002
6,667,315 Cardioprotective phosphonates and malonates 5 2002
6,867,215 Cardioprotective phosphonates and malonates 5 2003
6,897,228 Pyridoxine and pyridoxal analogues: new uses 5 2003
7,132,430 Treatment of cardiovascular and related pathologies 5 2003
7,125,889 Treating of cardiovascular and related pathologies 5 2003
7,115,625 Treatment of cardiovascular and related pathologies 7 2003
7,115,626 Treatment of cardiovascular and related pathologies 5 2003
7,442,689 Cardioprotective phosphonates and malonates 0 2003
7,459,468 Aryl sulfonic pyridoxines as antiplatelet agents 1 2004
7,425,570 Pyridoxine and pyridoxal analogues: new uses 0 2004
7,812,037 Dual antiplatelet/anticoagulant pyridoxine analogs 0 2005
 
QUERCEGEN PHARMA LLC (7)
7,745,486 Quercetin-containing compositions 0 2007
7,745,487 Method for enhancing physical performance or immune system recovery from intense physical excercise with quercetin-containing compositions 0 2007
8,574,619 Reducing cholesterol levels with combined use of quercetin and statin 0 2008
8,202,900 Method for stabilizing quercetin 1 2008
8,044,096 Method for treating addiction using quercetin-containing compositions 0 2009
8,440,704 Quercetin-containing compositions 0 2009
8,507,548 Method for treating addiction using quercetin-containing compositions 0 2011
 
BIODERM, INC. (6)
6,217,914 Ascorbic acid composition and method for treatment of aging or damaged skin 16 1999
6,444,699 Method for treatment of aging or damage skin 11 2000
8,003,134 Ascorbic acid composition and method for treatment of aging or damaged skin 0 2001
7,816,402 Compositions and methods for the treatment of skin 0 2001
7,670,620 Topical composition for the treatment of psoriasis and related skin disorders 1 2002
7,834,055 Compositions and methods for the treatment of skin 0 2008
 
THETA BIOMEDICAL CONSULTING & DEVELOPMENT CO., INC. (6)
6,984,667 Synergistic proteoglycan compositions for inflammatory conditions 6 2001
7,799,766 Composition for treating hormonally-dependent cancers 0 2004
7,906,153 Anti-inflammatory compositions for treating multiple sclerosis 7 2005
7,759,307 Compositions for protection against superficial vasodilator flush syndrome, and methods of use 0 2007
7,923,043 Method for protecting humans against superficial vasodilator flush syndrome 0 2008
8,268,365 Anti-inflammatory compositions for treating brain inflammation 0 2010
 
Advanced Medical Instruments (4)
6,346,519 Method and composition for treating arthritis 35 1999
6,573,299 Method and compositions for treatment of the aging eye 40 1999
7,846,914 Composition for the treatment and prevention of endothelial dysfunction 5 2005
8,486,889 Composition and method for the treatment and prevention of endothelial dysfunction 0 2012
 
The Procter & Gamble Company (4)
6,224,888 Cosmetic compositions 47 1999
6,455,055 Cosmetic compositions 3 1999
6,309,657 Cosmetic compositions 4 1999
6,528,071 Cosmetic compositions 10 2001
 
ChronoRX, LLC (3)
6,231,889 Unit dosage forms for the treatment of herpes simplex 12 1999
6,632,445 Unit dosage forms for the treatment of herpes simplex 5 2002
7,351,715 Unit dosage forms for the treatment of herpes simplex 3 2003
 
TRISTRATA, INCORPORATED (3)
RE41339 N-acetyl aldosamines, N-acetylamino acids and related N-acetyl compounds and their topical use 3 2006
RE41278 N-acetyl aldosamines and related N-acetyl compounds, and their topical use 1 2006
RE42902 N-acetyl aldosamines, N-acetylamino acids and related N-acetyl compounds and their topical use 0 2009
 
UNIVERSITY OF MANITOBA (3)
6,043,259 Treatment of cardiovascular and related pathologies 36 1999
6,890,943 Pyridoxal analogues and methods of treatment 10 2001
7,230,009 Pyridoxal analogues and methods of treatment 7 2003
 
Merrill Lynch Capital Canada Inc. (2)
7,148,233 Treatment of cardiovascular and related pathologies 5 2003
7,144,892 Treatment of cardiovascular and related pathologies 5 2003
 
METAGENICS, INC. (2)
6,534,086 Composition and method for treatment of inflammation and pain in mammals 13 2000
6,949,260 Method for treatment of inflammation and pain in mammals 3 2003
 
Murad, Inc. (2)
7,452,527 Methods of promoting hair growth 5 2003
8,318,140 Methods for promoting hair growth 0 2008
 
ARCH DEVELOPMENT CORPORATION (1)
6,576,660 Methods and compositions for regulation of 5-.alpha.-reductase activity 43 2000
 
BONNE BELL, INC. (1)
6,723,307 Cosmetic lip product with sour flavor 0 2002
 
BOTICA COMERCIAL FARMACEUTICA LTDA. (1)
7,576,045 Use of vinic alcohol in personal care products, cosmetics and perfumes 0 2005
 
HEALTH OPTIONS, INC. (1)
6,333,304 Therapeutic compositions containing glucosamine, collagen and a bioflavanol for repair and maintenance of connective tissue 13 1999
 
HENKAN PHARMACEUTICAL CO., LTD. (1)
7,655,255 Topical composition for transdermal administration 0 2004
 
KYOWA HAKKO KOGYO CO., LTD. (1)
6,685,970 Compositions containing proanthocyanidin and a vitamin B6 derivative or a salt thereof 1 2000
 
L'OREAL (1)
6,753,000 Hydroxystilbene/ascorbic acid compositions for treating skin afflictions 26 2002
 
LABORATOIRES EXPANSCIENCE (1)
8,466,109 Cosmetic method for preventing and/or treating skin stretchmarks, and use in dermatology 0 2004
 
MATRIX DESIGN (1)
6,808,707 Wound healing compositions and methods using tropoelastin and lysyl oxidase 11 2000
 
MEDESTEA INTERNAZIONALE S.R.L. (1)
7,261,908 Composition based on natural substances useful in the maintenance of the correct hydration of the skin 0 2004
 
Medicore, Inc. (1)
6,339,085 Therapeutics for cardiovascular and related diseases 19 2000
 
MEDICURE INC. (1)
6,489,345 Treatment of diabetes and related pathologies 9 2000
 
NATUROPATHIC LABORATORIES INTERNATIONAL, INC. (1)
6,482,401 Composition for the relief of joint pain and myofascial pain and method of preparing same 2 1999
 
Nutriex, L.L.C. (1)
6,579,544 Method for supplementing the diet 58 2000
 
Ocular Technologies, Inc. (1)
7,282,225 Composition and methods for improving retinal health 9 2006
 
REXAL SUNDOWN, INC. (1)
6,358,526 Method of making tablets and tablet compositions produced therefrom 15 2000
 
UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC. (1)
7,332,152 Cosmetic composition 1 2004
 
UNIVERSITY OF CHICAGO, THE (1)
6,696,484 Method and compositions for regulation of 5-alpha reductase activity 19 2002
 
UNIVERSITY TECHNOLOGY CORPORATION (1)
6,489,308 Inhibitors of serine protease activity, methods and compositions for treatment of nitric-oxide-induced clinical conditions 16 2000
 
VECTURA LIMITED (1)
7,928,089 Mucoactive agents for treating a pulmonary disease 2 2004
 
YAIZU SUISANKAGAKU INDUSTRY CO., LTD. (1)
6,919,306 Method of skin care 0 2002
 
Other [Check patent profile for assignment information] (7)
5,962,517 Pharmaceutical compositions and methods for treating acne 39 1998
6,641,806 Proteoglycan compositions for treating arthritic inflammatory conditions 3 2002
6,624,148 Proteoglycan compositions for treatment of cardiovascular inflammatory diseases 3 2002
7,482,026 Compositions and methods directed towards sore muscles and joints 0 2004
7,494,674 Nutraceutical with tart cherries and method of treatment therewith 0 2006
7,871,609 Supplements for pain management 1 2008
RE44302 N-acetyl aldosamines, N-acetylamino acids and related N-acetyl compounds and their topical use 0 2010