Methods and devices for the delivery of monomeric proteins
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United States of America Patent
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Sep 15, 1998
Grant Date -
N/A
app pub date -
Nov 12, 1996
filing date -
Nov 13, 1995
priority date (Note) -
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Abstract
Methods and devices for dissociating multimeric proteins and their delivery to patients, along with resultant compositions, are provided. A monomeric protein delivery device is also provided, comprising a supply of a multimeric protein 4, complex, comprising multimeric protein and an aggregating agent; a flow path having a subcutaneous exit 8, fluidly coupling the multimeric protein supply to the exit; a porous surface assembly situated along the flow path comprising a porous surface 10; and an aggregating agent binding partner carried by the surface 12; whereby the aggregating agent of the multimeric protein complex passing along the surface is bound to the binding partner on the surface to create a monomeric protein flow through the subcutaneous exit.
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