Collagen-based injectable drug delivery system and its use
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United States of America Patent
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Sep 15, 1998
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N/A
app pub date -
Sep 29, 1995
filing date -
Feb 9, 1994
priority date (Note) -
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Abstract
Drugs are delivered in a sustained manner from an in vivo depot which is formed from a collagen-based injectable composition. The injectable composition is fluid when injected but undergoes crosslinking in situ to form a crosslinked collagen matrix which encloses the drug to be released. The composition also includes a flexible chain polymer which is similarly charged to the precrosslinked collagen. This flexible chain polymer is enclosed in the matrix as well when the matrix forms and alters the effective porosity of the matrix. The drug diffuses out of the matrix at a rate which depends upon the matrix's effective porosity.
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