Preparation of brominated paclitaxel analogues and their use as effective antitumor agents
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United States of America Patent
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Sep 15, 1998
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May 29, 1996
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Dec 13, 1995
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Abstract
Provided are novel paclitaxel analogues, namely selectively brominated stereospecific derivatives of cephalomannine and 7-epi-cephalomannine having in vivo and in vitro paclitaxel-like antitumor efficacy, methods of preparation therefor and methods for treating tumors with these compounds.
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