Method for controlling O-desulfation of heparin
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United States of America Patent
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Sep 15, 1998
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app pub date -
Apr 10, 1997
filing date -
Dec 22, 1992
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Abstract
Methods of making and using, as prophylactics or therapeutics for preventing or treating certain diseases including cancer, O-desulfated heparin compositions, preferably 2-O, 3-O desulfated heparin compositions, wherein the methods permit regulating the degree of 2-O, 3-O desulfation to produce compositions that are variably desulfated upto about 99% and 75% desulfated at the 2-O and 3-O positions, respectively.
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